Reza KHEİRANDİSH, Baharak AKHTARDANESH, Nasrin ASKARİ

Spontaneous lymphoma in a Golden hamster (Mesocricetus auratus)

Mevcut klinik olguda, bir Golden hamsterda spontan lenfoma olgusu tartışıldı. Veteriner hastanesine iki haftadır süren kilo kaybı, iştahsızlık, ishal ve servical lenf nodüllerinde belirgin şişkinlikle karakterize erkek hamster getirildi. Fiziksel muayenede yaygın lenfadenomegali ve dehidrasyon belirlendi. Periton içi hidrokortizon ve dekstroz uygulamaları yapılmasına rağmen hasta öldü. Nekropside bütün süperfisial lenf yumrularında önemli büyümeler gözlendi. Ancak mezenterik, dalak ve karaciğer lenf yumrularının normal olduğu gözlendi. Diseke edilen lenf nodülleri merkezinde nekrozlar tespit edildi. Histopatolojik incelemede orta derecede mitotik indeksli büyük veziküler çekirdek içeren lenfoid hücreler belirlendi. Mevcut bulgular diffuz büyük B hücreli lenfomalı non-Hodgkin tanısını koydurdu. Laboratuvar hayvanlarında deneysel lenfomalar yapılmasına rağmen hamsterlarda spontan lenfomalar çok nadir gözlenmektedir. Mevcut klinik rapor spontan lenfomanın klinik ve histopatalojik varlığını tanımlandı.

Bir Golden hamsterda (Mesocricetus auratus) spontan lenfoma

In this clinical report, occurrence of a spontaneous lymphoma was discussed in a Golden hamster. Male hamster was referred to the veterinary hospital with a history of anorexia, diarrhea, prominent swelling of cervical lymph nodes and progressive weight loss since two weeks ago. During physical examination generalized lymphadenomegaly and severe dehydration was seen. Intraperitoneal dextrose and hydrocortisone was injected but the patient died. In necropsy, significant enlargements of all superficial lymph nodes were observed but the mesenteric lymph nodes, spleen, and liver were seemed normal. Dissected lymph nodes showed necrotized center. Histopathologic examination revealed lymphoid cells containing large vesicular nuclei with evident nucleoli which showed moderate mitotic index. On the basis of these findings, a definitive diagnosis of non-Hodgkin diffuse large B-ceIl lymphoma was made. Experimentally induced lymphomas have been reported in laboratory animals; however, spontaneously occurring lymphomas have been infrequently described in hamsters. This clinical report describes the clinical and histopathological aspects of a spontaneous lymphoma.

PDF

___

Antinoff N, Hahn K, 2004. Ferret oncology: Diseases, diagnosis and therapeutics. Vet Clin Exot Anim Pract, 7, 549-625.
Coggin JH, Bellomy BB, Thomas KV, Pollock WJ, 1983. B-cell and T-cell lymphomas and other associated diseases induced by an infectious DNA viroid-like agent in hamsters (Mesocricetus auratus). Am J Pathol, 110, 254-266.
Diamandopoulos GT, 1972. Leukemia, lymphoma and osteosarcoma induced in the Syrian golden hamster by simian virus. Science, 176, 173-175.
Graffi A, Bender E, Schramm T, Kuhn W, Schneiders F, 1969. Induction of transmissible lymphomas in Syrian hamsters by application of DNA from viral hamster papova virus-induced tumors and by cell-free filtrates from human tumors. Proc Nat Acad Sci, 64, 1172-1175.
Harkness JE, Wagner JE, 1995. Neoplasia in the hamster, In: The Biology and Medicine of Rabbits and Rodents, Williams Rodents, Williams & Wilkins, Philadelphia, USA, pp; 254-255.
Homburger F, 1983. Background data for tumor incidence in control animals (Syrian hamsters). Prog Exp Tumor Res, 26, 259-265
Keebl E, Meredith A, 2006. Rodent biology and husbandry. In: BSAVA manual of rodent and ferret, exotic pets. British small animal veterinary association. Gloucester, UK, pp; 12.
Lt H, Hesse B, Goerttler K, 1984. A spontaneous trans plantable lymphosarcoma of the Syrian golden hamster (Mesocricetus 11-auratus): Experimental induction of metastases after subcutaneous and intravenous inoculation. Exp Pathol, 25, 57-63.
Mc Martin DN, 1979. Morphologic lesions in aging Syrian hamsters. J Gerontol, 34, 502-511.
Pour P, Mohr U, Althoff J, Cardesa A, Kmoch N, 1976. Spontaneous tumors and common diseases in two colonies of Syrian hamsters. IV. Vascular and Iymphatic systems and lesions of other sites. J Nat Cancer Inst, 56, 963-974.
Strandberg JD, 1987. Neoplastic diseases. In: Vanhoosier Junior GL, Mc Pherson CW, eds; Laboratory Hamsters. Academic Press, Orlando, USA, pp; 157-178.
Vanhoosier-Junior GL, Trentin JJ, 1979. Naturally occurring tumors of the Syrian hamster. Prog Exp Tumor Res, 23, 1-12.