Ozgur KANAT, Dursun Ali DINC, Mehmet MADEN, Ayse Merve KOSE, Sakine Ulkum CİZMEZİ, Ibrahim AYDIN

Disseminated metastatic transmissible venereal tumour in a bitch

Bu vakanın materyalini doğum sonrası üç aydır devam eden kanlı vaginal akıntısı olan 4 yaşlı Sibiryan Husky ırkı dişi bir köpek oluşturdu. Yapılan fiziksel muayenede deri altında birçok noktada çeşitli büyüklükte kitlelerin olduğu, kanlı vajinal akıntının bulunduğu, vulvanın ödemli olduğu ve üzerinde dokunulduğunda kolayca kanayan karnabahar görünümlü frajil tümoral kitlelerin bulunduğu belirlendi. Vaginadaki tümoral kitlelerden hazırlanan smear preperatlarının sitolojik incelemesinde yuvarlak hiperkromik çekirdek ve çekirdekçiği bulunan ince stoplazmalı, eozinofilik vakuollü yuvarlak, oval ya da polihidral görünümlü tipik transmissible venereal tümör hücrelerine rastlandı. Ultrasonografik muayenede ise karaciğer, dalak ve sol böbreğin ekojenitelerinde değişiklik olduğu, karaciğer ve dalağın büyüdüğü ayrıca karaciğer üzerinde çok sayıda dalakta ise bir adet kitle olduğu belirlendi. Yapılan klinik, labaratuar, radyografik ve ultrasonografik muayeneler sonucunda vakada yaygın metastazlı transmissible venereal tümör (TVT) teşhis edildi. Vakanın prognozunun kötü olması nedeniyle hasta uyutuldu. Nekropsi sırasında deri, derialtı, memelerin etrafı, son kosta üzerie, abdomen, akciğer, karaciğer ve dalakta matastazik kitleler belirlendi. Genellikle benign karakterde olan ve metastazlara nadir rastlanılan TVT olgusu, bu vakada deri, derialtı dokular, meme, karaciğer, dalak ve akciğerde metastazlara yol açıp malign karaktere döndüğü belirlendi. Sonuç olarak TVTli köpeklerde metastaz varlığının araştırılması için dikkatli bir sistematik muayene yapılmalıdır.

Bir köpekte yaygın metastazlı transmissible venereal tümör

The material of this case is a 4-years-old Siberian Husky bitch with 3 months of continuous postpartum bloody vaginal discharge complaints. There were subcutaneous masses in various sizes in many points, vaginal bloody discharge, edematous vulva with fragile and easily bleeding on touch, cauliflower looking tumoral masses as noticed during physical examination. Typical transmissible venereal tumor (TVT) cells, shaped round, ovoid or polyhedral with eosinophylic vacuole, thin cytoplasm, round hyperchromatic nucleus and nucleolus were observed on cytological examination of smears prepared from tumoral masses in vagina. There were changes in echogenities of liver, spleen and left kidney, hepatomegaly, spleenomegaly and besides many mass formations in liver and one in spleen on ultrasonographic examinations. Disseminated metastasized TVT was diagnosed in the bitch depending on clinical, laboratory, radiographic and ultrasonographic examinations. Prognosis of the case was bad thus the patient was euthanized. Metastasized masses were observed during necropsy in skin, subcutaneous and around the udders, on the last rib, in abdomen, lung, liver and spleen. It was observed that TVT case, which is benign usually and metastatic rarely, turned malign and metastasized to skin, subcutaneous tissue, udders, liver, spleen and lung. In conclusion, a careful systemic examination and inquiring the presence of metastasis should be considered in dogs with TVT.

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