Hasan GÜZELBEKTEŞ², Mutlu SEVİNÇ, Şebnem Canikli ENGİN

Sağlıklı, ishalli ve prematüre buzağılarda eritromisin ve betanekolün abomazal boşalma oranına etkisi

Amaç: Bu araştırmada sağlıklı, ishalli ve prematüre buzağılarda, prokinetik ajanlardan olan eritromisin ve betanekolün abomazal boşalma oranı üzerine etkisini belirlemek amaçlanmıştır. Gereç ve Yöntem: Araştırmada 5 adet sağlıklı, 12 adet ishalli ve 12 adet prematüre buzağı kullanıldı. Bu üç gruptaki buzağılar da kendi aralarında da gruplandırılarak, bir gruba IM 10 mg/kg dozunda eritromisin verildi, bir gruba IM 0,07 mg/kg dozunda betanekol verildi, bir diğer gruba ise herhangi bir ilaç uygulaması yapılmadı ve ardından tüm gruplara süt ikamesi içirildi. Gastrointestinal motiliteyi asetaminofen ve glikoz absorbsiyon testleri ile değerlendirmek amacıyla, içirilen her süt ikamesi içerisine 50 mg/kg asetaminofen ve 25 gram/L glikoz ilavesi yapıldı. Süt ikamesi içirilmeden önce (0. değer) ve içirildikten sonra ki 30, 60, 90, 120, 180, 240 ve 300. dakikalarda kan örnekleri toplandı. Ayrıca deneme süresince buzağıların solunum sayıları ve kalp atım sayıları da kayıt edildi.Bulgular: Tüm gruplarda, ilaç uygulamasını takiben solunum sayıları, nabız sayıları ve genel durumlarında bir değişiklik gözlenmedi. Buzağıların bazılarında dışkının hafif sulu kıvama geldiği, prematüre buzağılarda genellikle 180 dk sonra dışkılama şekillendiği gözlendi. Prematüre gruptaki buzağılarda eritromisin uygulaması sonrasında asetaminofen ve glikoz Cmax, Tmax ile AUC değerleri kontrol grubu ile karşılaştırıldığında, daha yüksek Cmax (P0,05) ve daha büyük AUC değerlerine (P>0,05) ulaştığı belirlendi.Öneri: Klinik ve laboratuvar bulgular temelinde prematüre buzağılara 10 mg/kg dozunda eritromisin IM uygulamasının daha hızlı abomazal boşalma sağlayabileceği ifade edilebilir.

The effects on abomasal emptying rate of erythromycin and bethanechol in healthy, premature and diarrheic calves

Aim: In this study, it is aimed that to be defined the effect of erythromycin and bethanechol which are from prokinetic agent on the value of discharge for the calves that are healthy, diarrheic and premature. Materials and Methods: : In the study, 5 healthy calves, 12 diarrheic calves and 12 premature calves were used. Each of these three groups are divided into three sub groups and it is applied 10 mg/kg IM dose of erythromycin, 0,07 mg/kg IM dose of bethanechol for two sub groups. For the last sub groups, those drugs have not been applied. 50 mg/kg acetaminophen and 25 gram/L glucose have been added in to the substitution of milk to evaluate the speed of gastrointestinal motility with the test results of absorptions of acetaminophen and glucose. The blood examples have been taken before substitution of milk application and for 30, 60, 90, 120, 180, 240 and 300th minutes after substitution of milk application.Results: The respiratory rates and number of heartbeats were also recorded during the test time. There are no changes was observed in number of heart beats, respiratory rates and general conditions for all groups after drugs applied. It is observed that, the feces of some calves were became slightly watery viscosity and premature calves generally defecated after 180 minutes. When Cmax, Tmax and AUC values of acetaminophen and glucose are compared with control group’s after applying erythromycin on the calves which are in premature group, it is defined the higher Cmax (P0,05) values.Conclusion: According to clinical and laboratory findings, it may be stated that the application of 10 mg/kg dose of erythromycin IM has provided faster abomasal emptying in premature calves

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