Koyunlarda diklofenak sodyum ve meloksikamın tekrarlı uygulanmasının koagulasyon parametreleri üzerine etkisi

Amaç: Bu çalışmada koyunlara diklofenak sodyum ve meloksikam uygulamasının koagulasyon parametreleri üzerine etkisinin belirlenmesi amaçlandı.Gereç ve Yöntem: Araştırmada Akkaraman ırkı, sağlıklı 12 adetkoyun kullanıldı. Koyunlar her grupta 6 adet olacak şekilde rastgele diklofenak sodyum (DS) ve meloksikam (MS) olmak üzereiki gruba ayrıldı. DS grubundaki koyunlara 2.5 mg/kg dozdadiklofenak sodyum, MS grubundaki koyunlara ise 0.5 mg/kgdozda meloksikam kas içi yolla günde bir defa 3 gün boyuncauygulandı. Kan örnekleri ilaç uygulamasından önce (0. saat) veilk ilaç uygulamasını takiben 72. saatte alındı. Plazma fibrinojen, aktive parsiyel tromboplastin zamanı (APPT), protrombinzamanı (PT), D-dimer ve trombosit (PLT) seviyeleri ölçüldü.Bulgular: Çalışma süresince her iki gruptaki hayvanların klinikmuayene bulgularında herhangi bir farklılık gözlenmedi. DS veMS grubunun 0. saat ile 72. saat örnekleri karşılaştırıldığındafibrinojen, APTT, PT, D-dimer ve PLT sonuçlarında istatiksel (P >0.05) bir farklılık görülmedi.Öneri: Koyunlara üç gün süre ile diklofenak sodyum ve meloksikam uygulamasının koagulasyon parametreleri üzerinde belirgin etkisinin olmadığı ifade edilebilir.

Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep

Aim: The aim of this study is to determine the effects of diclofenac sodium and meloxicam administrations on coagulation parameters in sheep. Materials and Methods: This study was carried out on 12 Akkaraman healthy sheep and they were divided into two groups as the diclofenac sodium group (DS) and meloxicam group (MS), equally. In the DS group, diclofenac sodium (2.5 mg / kg) and in MS group, meloxicam (0.5 mg / kg) was administered intramuscularly once daily for 3 days. Blood samples were taken before the drug administration (0 h) and at 72 hours following administration. The plasma fibrinogen, activated partial thromboplastin time (APTT), prothrombin time (PT), D-dimer and platelet count (PLT) levels were determined at 0 and 72 hours. Results: During the study, there was no difference in the clinical examination findings of the groups. No statistically differences (P > 0.05) were found in fibrinogen, APTT, PT, D-dimer, and PLT parameters in the DS and MS groups at 0 and 72 hours. Conclusion: It may be stated that administrations of diclofenac sodium and meloxicam for 3 days in sheep may not cause any change in the coagulation parameters.

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EMEA 2003. EMEA/MRL/885/03. Erişim tarihi 2 Mayıs 2018.
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