Levent ALTINTAS, Mert PEKCAN, Ender YARSAN, Gulay CİFTCİ, Arif ALTINTAS, Dinc ESSİZ, Ishraga G. IBRAHİM

Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice

Yarsan E, Altıntaş A, Eşsiz D, Altıntaş L, Pekcan M, Çiftci G, İbrahim IG. Farelerde Cıva Klorür ile Oluşturulan Böbrek Hasarının Oral Yolla Uygulanan Sülfametaksazolün Farmakokinetiği Üzerine Etkisi. Eurasian J Vet Sci, 2010, 26, 1, 21-24 Amaç: Bu çalışmada, deneysel olarak cıva klorür ile böbrek hasarı oluşturulmuş farelerde 100 mg/kg dozda oral yolla uygulanan sülfametoksazolün farmakokinetiği değerlendirildi. Gereç ve Yöntem: Cıva klorür farelere 3 ve 6 mg/kg dozlarında verildi. Plazma sülfametaksazol konsantrasyonları spektrofotometre ile ölçüldü. Plazma konsantrasyon-zaman verileri dikkate alındığında ilacın 2 kompartmanlı açık modele uygun olduğu görüldü. Bulgular: Böbrek hasarı ile ilişkili olarak sülfametoksazolün emilim (AUC and $t_{1/2a}$) ve eliminasyon ($t_{1/2beta}$ and MRT) fazlarında önemli bulgular (p

Deneysel olarak civa klorür ile böbrek hasarı oluşturulan farelerde sülfametaksazolün farmakokinetiğinin değerlendirilmesi

Yarsan E, Altintas A, Essiz D, Altintas L, Pekcan M, Ciftci G, Ibrahim IG. Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian J Vet Sci, 2010, 26, 1, 21-24 Aim: The effects of renal failure on the pharmacokinetics of sulphamethoxazole were investigated after oral administration of 100 mg/kg of the drug using a mice model of mercury chloride-induced renal failure. Materials and Methods: Mercury chloride was given to mice at the doses of 3 and 6 mg/kg. Plasma sulphamethoxazole concentrations were measured by spectrophotometer. Plasma concentration-time data were fitted to a two-compartment open model. Results: Significant findings (p

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