İnci Başak KAYA, Hakan YARDIMCI

Quorum Sensing

Günümüzde hücreler arası iletişim ve işbirliğinin sadece ökaryotlarda olmadığı prokaryotlarda da hücreler arası iletişimin var olduğu anlaşılmıştır. Bakteriler arası bu iletişim quorum sensing (QS) olarak tanımlanmaktadır. Quorum sensing bakteriye çok hücreli organizma gibi davranma yeteneği kazandırmaktadır. Bakteriler, diğer bakteriler tarafından üretilen ve oto indükleyici olarak adlandırılan küçük hormon benzeri molekülleri spesifik deteksiyon sistemleri kullanarak uyarıcı düzeydeki konsantrasyonlarını tespit eder. Böylece gen ekspresyonlarını ve dolayısıyla davranışlarını değiştirirler. Bakteri, bu sinyal-yanıt sistemini kullanarak, popülasyon düzeyinde bireysel davranışlarını sekronize eder ve çok hücreli organizma gibi davranır. Bu makale de prokaryotik hücreler arası ve prokaryot ile ökaryotik hücreler arası quorum sensing mekanizmaları derlenmiştir.

Anahtar Kelimeler:

Quorum sensing, prokaryot, regülon, ökaryot, iletişim., Hakan YARDIMCI, İnci Başak KAYA, Etlik Veteriner Mikrobiyoloji Dergisi, 2014

Quorum Sensing

Nowadays, cell to cell communication and co-operation has been proved to be not only found in eukaryotes, but also in prokaryotes. In bacteria, this communication is termed quorum sensing (QS). QS enables bacteria to act as multicellular organisms. Bacteria determine small hormone-like molecules termed auto inducer which produced by another bacteria by using specific detection systems. Thus, they transform gene expression, and therefore behavior. Using these signal-response systems, bacteria synchronize particular behavior on a population wide scale and function as multicellular organisms. In this article, mechanism of cell to cell communication between prokaryotic cell and prokaryote and eukaryotic cells are considered.

Keywords:

Communication, eukaryote, prokaryote, regulon, quorum sensing.,

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