Tonsillotomi hasta seçiminde nötrofil-lenfositoranı, trombosit-lenfosit oranı ve MPV inflamasyonbelirteci olarak kullanılabilir mi?

Amaç: Bu çalışmanın amacı uyku apnesi nedeni ile tonsillotomi yapılması planlanan pediatrik hastaların seçiminde ortalama trombosit hacmi(OTH), nötrofil-lenfosit oranı (NLO) ve trombosit-lenfosit oranının(TLO) inflamasyon belirteci olarak kullanılıp kullanılmayacağını araştırmaktır. Yöntem:2013-2015 yılları arasında uyku apnesi nedeni ile tonsillotomiyapılan pediatrik hastalar tonsillotomi grubunu oluşturdu. Sağlam çocukpolikliniğine başvuran pediatrik hastalar ise kontrol grubunu oluşturdu.Hastaların dosyaları retrospektif olarak incelendi. OTH, NLO ve TLOdeğerleri kaydedildi ve analiz edildi. Bulgular:Tonsillotomi grubunda 23, kontrol grubunda 31 hastamevcuttu. Tonsillotomi grubunda medyan yaş ortalaması 5, kontrolgrubunda 6 idi. OTH, NLO VE TLO değeri tonsillotomi ve kontrolgrubunda istatistiksel olarak anlamlı farklılık göstermiyordu (p=0.838,p=0.314 ve p=0.896). Sonuç:OTH, NLO ve TLO değerleri, uyku apnesi nedeni ile tonsillotomi yapılması planlanan hastaların seçiminde kullanılabilecekinflamasyon belirteçleri değildir.

Can neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and mean platelet volume be used as inflammation markers in patient selection for tonsillotomy?

Objective:The aim of this study was to investigate whether meanplatelet volume (MPV), neutrophil-lymphocyte ratio (NLR) andplatelet-lymphocyte ratio (PLR) can be used as inflammation markersin selection of pediatric patients, who were planned to undergo tonsillotomy for sleep apnea, or not. Methods:The tonsillotomy group consisted of pediatric patients whohad undergone tonsillotomy for sleep apnea between 2013-2015 years.The control group consisted of children who had presented to the WellChild Outpatient Clinics. The patient charts were reviewed retrospectively. MPV, NLR and PLR values were recorded and analyzed. Results: In the tonsillotomy group, there were 23 patients whereas thecontrol group consisted of 31 healthy children. The median age was 5 inthe tonsillotomy group and 6 in the control group. MPV, NLR and PLRvalues did not have statistically significant differences between the tonsillectomy and control groups (p=0.838, p=0.314 and p=0.896, respectively).Conclusion:MPV, NLR and PLR values are not inflammationmarkers that can be used in selection of patients to undergo tonsillotomy for sleep apnea.

___

  • 1. Wang H, Fu Y, Feng Y, Guan J, Yin S. Tonsillectomy versus tonsillotomy for sleep-disordered breathing in children: a meta-analysis. PLoS One 2015;10(3):e0121500.
  • 2. Bhattacharyya N, Kepnes LJ. Revisits and postoperative hemorrhage after adult tonsillectomy. Laryngoscope 2014;124:1554-6.
  • 3. Gysin C, Dulguerov P. Hemorrhage after tonsillectomy: does the surgical technique really matter? ORL J Otorhinolaryngol Relat Spec 2013;75:123-32.
  • 4. Kaygusuz I, Alpay HC, Gödekmerdan A, et al. Evaluation of longterm impacts of tonsillectomy on immune functions of children: a follow-up study. Int J Pediatr Otorhinolaryngol 2009;73:445-9.
  • 5. Cengiz C, Erhan Y, Murat T, et al. Values of mean platelet volume in patients with chronic tonsillitis and adenoid hypertrophy. Pak J Med Sci 2013;29:569-72.
  • 6. Varol E, Ozturk O, Gonca T, et al. Mean platelet volume is increased in patients with severe obstructive sleep apnea. Scand J Clin Lab Invest 2010;70:497-502.
  • 7. Onder S, Caypinar B, Sahin-Yilmaz A, Toros SZ, Oysu C. Relation of mean platelet volume with obstructive adenoid hypertrophy in children. Int J Pediatr Otorhinolaryngol 2014;78:1449- 551.
  • 8. Baugh RF, Archer SM, Mitchell RB, et al.; American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg 2011;144(1 Suppl):S1-30.
  • 9. Windfuhr JP, Werner JA. Tonsillotomy: it's time to clarify the facts. Eur Arch Otorhinolaryngol 2013;270:2985-96.
  • 10. de la Chaux R, Klemens C, Patscheider M, Reichel O, Dreher A. Tonsillotomy in the treatment of obstructive sleep apnea syndrome in children: polysomnographic results. Int J Pediatr Otorhinolaryngol 2008;72:1411-7.
  • 11. Pfaar O, Spielhaupter M, Schirkowski A, et al. Treatment of hypertrophic palatine tonsils using bipolar radiofrequency-induced thermotherapy (RFITT). Acta Otolaryngol 2007;127:1176-81.
  • 12. Lister MT, Cunningham MJ, Benjamin B, et al. Microdebrider tonsillotomy vs electrosurgical tonsillectomy: a randomized, double-blind, paired control study of postoperative pain. Arch Otolaryngol Head Neck Surg 2006;132:6:599-604.
  • 13. Huber K, Sadick H, Maurer JT, Hörmann K, Hammerschmitt N. Tonsillotomy with the argon-supported monopolar needle - first clinical results. [Article in German] Laryngorhinootologie 2005; 84:671-5.
  • 14. Arya AK, Donne A, Nigam A. Double-blind randomized controlled study of coblation tonsillotomy versus coblation tonsillectomy on postoperative pain in children. Clin Otolaryngol 2005;30: 226-9.
  • 15. Goldbart AD, Mager E, Veling MC, et al. Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. Pediatr Res 2007;62:489-94.
  • 16. Svensson M, Venge P, Janson C, Lindberg E. Relationship between sleep-disordered breathing and markers of systemic inflammation in women from the general population. J Sleep Res 2012;21:147-54.
  • 17. Kim J, Hakim F, Kheirandish-Gozal L, Gozal D. Inflammatory pathways in children with insufficient or disordered sleep. Respir Physiol Neurobiol 2011;178:465-74.
  • 18. Imeri L, Opp MR. How (and why) the immune system makes us sleep. Nat Rev Neurosci 2009;10:199-210.
  • 19. Vgontzas AN. Does obesity play a major role in the pathogenesis of sleep apnoea and its associated manifestations via inflammation, visceral adiposity, and insulin resistance? Arch Physiol Biochem 2008;114:211-23.
  • 20. Yu YH, Ginsberg HN. Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue. Circ Res 2005;96: 1042-52.
  • 21. Faraut B, Boudjeltia KZ, Vanhamme L, Kerkhofs M. Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery. Sleep Med Rev 2012;16:137-49.
  • 22. Sagit M, Korkmaz F, Kavugudurmaz M, Somdas MA. Impact of septoplasty on mean platelet volume levels in patients with marked nasal septal deviation. J Craniofac Surg 2012;23:974-6.
  • 23. Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol 2013;88:218-30.
  • 24. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008;102:653-7.
  • 25. Yenigun A, Karamanli H. Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome. J Laryngol Otol 2015;129:887-92.
  • 26. Korkmaz M, Korkmaz H, Küçüker F, Ayy>ld>z SN, Çankaya S. Evaluation of the association of sleep apnea-related systemic inflammation with CRP, ESR, and neutrophil-to-lymphocyte ratio. Med Sci Monit 2015;13:477-81.
  • 27. Koseoglu S, Ozcan KM, Ikinciogullari A, Cetin MA, Yildirim E, Dere H. Relationship between neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and obstructive sleep apnea syndrome. Adv Clin Exp Med 2015;24:623-7.
  • 28. Wang D, Yang JX, Cao DY, et al. Preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma. Onco Targets Ther 2013;6:211-6.
  • 29. Gary T, Pichler M, Belaj K, et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PLoS One 2013;8:e67688.
  • 30. Azab B, Shah N, Akerman M, McGinn JT Jr. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST-elevation myocardial infarction. J Thromb Thrombolysis 2012;34:326-34.
  • 31. Raungkaewmanee S, Tangjitgamol S, Manusirivithaya S, Srijaipracharoen S, Thavaramara T. Platelet to lymphocyte ratio as a prognostic factor for epithelial ovarian cancer. J Gynecol Oncol 2012;23:265-73.
  • 32. Koseoglu HI, Altunkas F, Kanbay A, Doruk S, Etikan I, Demir O. Platelet-lymphocyte ratio is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome. J Thromb Thrombolysis 2015;39:179-85.
ENT Updates-Cover
  • ISSN: 2149-7109
  • Başlangıç: 2015
  • Yayıncı: Prof.Dr.Murat Demir
Sayıdaki Diğer Makaleler

Submandibüler bezde siyalolityaz ve aktinomikozun seyrek görülen birlikteliği

Oğuzhan DİKİCİ, Nuray Bayar MULUK

Endotelyal nitrik oksit sentaz (eNOS) ve miyeloperoksidaz (MPO) genlerin mikrotiyadaki rolü

Berker BÜYÜKGÜRAL, SACİDE PEHLİVAN, AYŞE FEYDA NURSAL, MEHMET BEKERECİOĞLU

Koenzim Q10'un ratlarda sıçanlarda sisplatininneden olduğu ototoksisiteye etkisi

Güler BERKİTEN, Tolgar Lütfi KUMRAL, Ziya SALTÜRK, Belgin TUTAR, Ayşe Enise GÖKER, Gürcan SÜNNETÇİ, YAVUZ UYAR, Hilmi UĞRAŞ

Akut parotit hastalarında parotis muayenesi vemasajın serum amilaz düzeylerine etkisi

MUHAMMED FATİH EVCİMİK, BURAK ÖMÜR ÇAKIR, Ahmet Adnan CIRIK, Raflit CEVİZCİ, Erkan SOYLU, Celal GÜNAY

Psoriasis hastalarında iflitmenin hastalığın fliddetine göre değerlendirilmesi

Aslı HAPA, Nilda SÜSLÜ, Ayşen KARADUMAN, BİLGEHAN BUDAK, Sibel Ersoy EVANS, Levent SENNAROĞLU

Ortalama trombosit hacmi ani işitme kaybı içinprediktif bir değer midir?

Hasan Emre KOÇAK, Harun ACIPAYAM, Mehmet KESKİN, Arzu Karaman KOÇ, Ayşe Pelin YİĞİDER, Fatma Tülin KAYHAN

Topikal dekspantenol uygulaması akut kulakzarı perforasyonlarının iyileşmesini hızlandırmaktadır:Deneysel bir çalışma

Sinem DEMİRDELEN, Mehmet İMAMOĞLU, Selçuk ARSLAN, İsmail SAYGIN

Tek bir ajan olarak setuksimab oral kavitekanser hücrelerinde doza bağımlı etkiye sahiptir: Bir in vitro çalışma

GÖRKEM ESKİİZMİR, GİZEM ÇALIBAŞI KOÇAL, TUĞBA UYSAL KILIÇ, Hülya ELLİDOKUZ, Yasemin BASKIN

Tonsillotomi hasta seçiminde nötrofil-lenfositoranı, trombosit-lenfosit oranı ve MPV inflamasyonbelirteci olarak kullanılabilir mi?

Yeşim BAŞAL, İMRAN KURT ÖMÜRLÜ, Pınar UYSAL, AYLİN ERYILMAZ, HATİCE SEMA BAŞAK

How much are the incidental abnormalities on brain MRI clinically significant in otolaryngology practice?

Çiğdem Kalaycık ERTUGAY, Ayça Özbal KOÇ, Halime ÇEVİK2, Selim Sermed ERBEK