Hasan Emre KOÇAK, Harun ACIPAYAM, Mehmet KESKİN, Arzu Karaman KOÇ, Ayşe Pelin YİĞİDER, Fatma Tülin KAYHAN

Ortalama trombosit hacmi ani işitme kaybı içinprediktif bir değer midir?

Amaç: İdiyopatik ani sensörinörinal işitme kaybının (AİK) etiyolojisindeviral enfeksiyonlar, mikrovasküler hasar ve inflamasyon başta olmak üzere birçok etken suçlanmıştır. Artmış ortalama trombosit hacmi (MPV)değerleri daha aktif enzimatik süreç ve trombosit predispozisyonu ile ilişkilidir. Çalışmanın amacı MPV ile AİK arasındaki ilişkiyi araştırmaktır. Yöntem:Çalışma retrospektif olarak hasta kayıtlarının taranması ile yapıldı. AİK tanısı konulan 93 hasta ve 93 sağlıklı kontrol grubu çalışmayadahil edildi. Grupların periferik kan MPV değerleri istatistiksel olarakkarşılaştırıldı. Bulgular:Her iki grup arasında MPV değerleri açısından istatistikselolarak anlamlı farklılık bulunmadı. Sonuç:Çalışmamızın sonuçlarına göre MPV, idiyopatik AİK içinprediktif bir parametre değildir.

Is mean platelet volume a predictive marker for sudden sensorineural hearing loss?

Objective:There are many factors considered to be related with theetiology of sudden sensorineural hearing loss (SSNHL) such as viralinfections, microvascular diseases and inflammation. Increased meanplatelet volume (MPV) levels are assumed to represent more activeenzymatic process and thrombotic predisposition. Our aim in this studyis to show whether MPV could be a predictive value in SSNHL or not. Methods:The medical records of a total of 93 patients with SSNHL and93 healthy controls were reviewed retrospectively in this study. Peripheralblood MPV values of both groups were compared statistically. Results: Mean platelet volume levels did not show a statistically significant difference between these groups. Conclusion:As a result of our study, we consider MPV is not a predictive parameter in idiopathic SSNHL.

PDF

___

1. Teranishi M, Katayama N, Uchida Y, Tominaga M, Nakashima T. Thirty-year trends in sudden deafness from four nationwide epidemiological surveys in Japan. Acta Otolaryngol 2007;127:1259-65.
2. Kakehata S, Sasaki A, Oji K, et al. Comparison of intratympanic and intravenous dexamethasone treatment on sudden sensorineural hearing loss with diabetes. Otol Neurotol 2006;27: 604-8.
3. Sagit M, Kavugudurmaz M, Guler S, Somdas MA. Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss. J Laryngol Otol 2013;127:972-6.
4. Suckfull M, Wimmer C, Reichel O, Mees K, Schorn K. Hyperfibrinogenemia as a risk factor for sudden hearing loss. Otol Neurotol 2002;23:309-11.
5. Gawaz M, Langer H, May AE. Platelets in infammation and atherogenesis. J Clin Invest 2005;115:3378-84.
6. Karli R, Alacam H, Unal R, Kucuk H, Aksoy A, Ayhan E. Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss? Indian J Otolaryngol Head Neck Surg 2013;65:350-3.
7. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983;32:443-60.
8. Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and metaanalysis. J Thromb Haemost 2010;8:148-56.
9. Bath P, Algert C, Chapman N, Neal B; PROGRESS Collaborative Group. Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease. Stroke 2004;35:622-6.
10. Pathansali R, Smith NM, Bath PM. Prothrombotic megakaryocyte and platelet changes in hypertension are reversed following treatment: a pilot study. Platelets 2001;12:144-9.
11. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96:776-81.
12. Ulu S, Ulu MS, Ahsen A, Yucedag F, Aycicek A, Celik S. Increased levels of mean platelet volume: a possible relationship with idiopathic sudden hearing loss. Eur Arch Otorhinolaryngol 2013;270:2875-8.
13. Blaha M, Kostal M, Drsata J, Chrobok V, Lanska M, Zak P. Does mean platelet volume really increase in sudden sensorial hearing loss? Eur Arch Otorhinolaryngol 2015;272:2575-8.
14. Cvorovic L, Jovanovic MB, Milutinovic Z, Arsovic N, Djeric D. Randomized prospective trial of hyperbaric oxygen therapy and intratympanic steroid injection as salvage treatment of sudden sensorineuralhearing loss. Otol Neurotol 2013;34:1021-6.
15. Lance MD, Sloep M, Henskens YM, Marcus MA. Mean platelet volume as a diagnostic marker for cardiovascular disease: drawbacks of preanalytical conditions and measuring techniques. Clin Appl Thromb Hemost 2012;18:561-8.
16. Ullrich D, Aurbach G, Drobik C. A prospective study of hyperlipidemia as a pathogenic factor in sudden hearing loss. Eur Arch Otorhinolaryngol 1992;249:273-6.
17. Hwang, J-H. Role of obesity on the prognosis of sudden sensorineural hearing loss in adults. Otolaryngol Head Neck Surg 2015;153:251-6.
18. Rajati M, Azarpajooh MR, Mouhebati M, et al. Is sudden hearing loss associated with atherosclerosis? Iran J Otorhinolaryngol 2016;28:189-95.