Aslı HAPA, Nilda SÜSLÜ, Ayşen KARADUMAN, BİLGEHAN BUDAK, Sibel Ersoy EVANS, Levent SENNAROĞLU

Psoriasis hastalarında iflitmenin hastalığın fliddetine göre değerlendirilmesi

Amaç: Günümüzde psoriasis otoinflamatuar/otoimmün bir hastalıkolarak kabul görmektedir. Kronik inflamasyonun sonucu olarak psoriasis efllik eden hastalıklar ve komorbiditeler için yaygın arafltırılmaktadır. Ancak psoriasisin iflitme fonksiyonları üzerine etkisi hakkındasınırlı veri bulunmaktadır. Çalıflmanın amacı psoriasisli hastalardasensörinöral iflitme kaybı ve hastalık fliddetinin iflitme düzeylerine etkisini prospektif olarak arafltırmaktı. Yöntem:Çalıflmaya toplamda 50 psoriasisli hasta (100 kulak) ve 45sağlıklı kontrol (90 kulak) dahil edildi. Katılımcılara otoskopik muayene sonrası yüksek frekansları da içeren hava ve kemik iletimi (500,1000, 2000, 4000, 8000, 16.000 Hz) ve konuflma odyometrisi uygulandı. Bulgular:Hastaların ortanca saf ses ortalaması kontrollerden anlamlı düzeyde farklıydı. Ayrıca psoriasisli hastaların her iki kulak için tümfrekans düzeyleri kontrol grubundakilerden anlamlı derecede farklıydı. Çalıflmanın kısıtlılığı olarak; hastalar psoriatik artrit açısından incelenmedi ve hastaların serumlarında anti-konneksin 26, antiDEP/CD148 ve anti 68K gibi içkulak antijenleri için antikorlar daarafltırılmadı. Sonuç:Kronik sistemik inflamasyonun bir sonucu olarak psoriasisteiçkulak tutulumu olasılığı akılda tutulmalıdır. Psoriasisli hastalar iflitme problemleri olmasa bile periyodik olarak odyometriyle değerlendirilebilirler.

Evaluation of hearing in patients with psoriasis considering the disease severity

Objective:Nowadays, psoriasis is accepted to be an autoinflammatory/autoimmune disease. As a result of chronic inflammation, psoriasis iswidely investigated for associated diseases and comorbidities. However,there are limited data about the effects of psoriasis on hearing functions.The aim of the study was to investigate prospectively if patients withpsoriasis have sensorineural hearing loss and the effect of the diseaseseverity on hearing levels. Methods:Overall, 50 patients (100 ears) with psoriasis and 45 healthycontrols (90 ears) were included in the study. After otoscopic examination, pure tone air and bone conduction including high frequencies(500, 1000, 2000, 4000, 8000, and 16,000 Hz) and speech audiometrywere performed to all participants. Results: Median pure tone average of the patients was significantly different than controls. Moreover, the frequency levels of patients withpsoriasis for both of the ears were all significantly different from thecontrol group. As the limitation of the study, patients were not investigated for psoriatic arthritis and sera from patients were also not investigated for anti-bodies for inner ear antigens such as anti-connexin 26,anti-DEP/CD148 and anti 68K. Conclusion:The possibility of inner ear involvement should be kept inmind in psoriasis as a result of chronic systemic inflammation. Patientswith psoriasis may be evaluated with audiometry periodically even ifthey do not exhibit any hearing problems.

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