Mehmet Zeynel KESKİN, Taha Reşi̇d ÖZDEMİR, Salih BUDAK, Yusuf Özlem İLBEY, Can KÖSE, Özge Özer KAYA

Klinefelter sendromlu azospermik olgularda testiküler sperm ekstraksiyonu (TESE) başarısı için prediktif faktörler

Amaç: Klinefelter sendromu (KS) olgularında testiküler sperm ekstraksiyonu (TESE) başarısı için prediktif parametrelerin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Çalışmamızda hastanemizde 2009-2014 yıllarında non-obstrüktif azospermi (NOA) nedeniyle TESE yapılmış 322 hastanın verileri retrospektif olarak incelendi. Bu hastalardan genetik analizi 47XXY - KS olarak saptanan 29 hasta çalışmaya alınarak yaş, FSH, LH, FSH/LH oranı, prolaktin, T ve E2 değerleri retrospektif olarak incelendi. Parametrelerin istatistiksel analizinde, p

Predictive factors for testicular sperm extraction (TESE) success in azoospermic cases with Klinefelter syndrome

Aim: It is aimed to identify the predictive factors for testicular sperm extraction (TESE) success in cases with Klinefelter syndrome (KS). Materials and Methods: We retrospectively analyzed 322 patients that underwent TESE operation because of nonobstructive azoospermia (NOA) in our hospital between 2009 and 2014. Twenty-nine patients whose genetic analysis reported 47XXY - KS were included in our study. Age, FSH, LH, FSH/LH ratio, prolactin, T and E2 values of these 29 patients were analysed retrospectively. In statistical analysis of these parameters, p value <0.05 was accepted as significant. Results: The mean age, FSH, LH, FSH/LH ratio, prolactin, T and E2 value of the patients were; 32 years, 38.4 mIU/mL, 18.84 mIU/mL, 2.04, 11 ng/mL, 216.74 ng/dL and 24.37 pg/mL, respectively. Our TESE success was 37.9 %. Age was the only predictive parameter for TESE success (p=0.007). Independent sample t test values of FSH, LH, FSH/LH ratio, prolactin, T and E2 were p=0.185; p=0.510; p=0.119; p=0.545; p=0.841; p=0.139 respectively and were non-predictive. Conclusion: In KS cases, the only predictive parameter for TESE success is age, except biopsy. TESE success was found significantly higher at 32 years of age and under.

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