Effect of exercise on erythrocyte osmotic fragility in high fat diet fed rats during intermittent fasting

Exercise is an important component of a healthy lifestyle. High fat diets are blamed for various health problems such as cardiovascular diseases. Intermittent fasting is a way of increasing longevity and decreasing certain adverse health conditions. In this study effect of exercise, intermittent fasting and high fat diet on erythrocyte osmotic fragility which is an important marker of erythrocyte integrity was investigated. 42 Wistar albino male rats were used in this study. Rats were divided into 7 groups in which each were composed of 6 animals. Exercise was administered 3 times a week. Intermittent fasting was administered 2 times a week (24 without any food in those two days). High fat was given in a high fat diet. Combination of applications was also administered in different groups. Results state an increase in erythrocyte osmotic fragility due to exercise. High fat or intermittent fasting did not cause in increase in fragility however they did not alleviate increased fragility due to exercise where they are concomitantly administered with exercise. Intermittent fasting administered solely or with high fat did not change erythrocyte osmotic fragility therefore stating no negative impact of intermittent fasting on this studied parameter. However no protective effect was observed in IF+Exe group. This result can also be interpreted with high impact of Exe in this study on the rats. Studies including molecular mechanism focusing on erythrocyte membrane lipid alterations should be performed to clarify current findings.

Kaynakça

1. Angliss R, Fujii G, Pickvance E, Wainwright AM, Benson MK. Surgical treatment of late developmental displacement of the hip results after 33 years. J Bone Joint Surg Br 2005; 87: 384-394.

2. Ning B, Yuan Y, Yao J, Zhang S, Sun J. Analyses of outcomes of one-stage operation for treatment of late-diagnosed developmental dislocation of the hip: 864 hips followed for 3.2 to 8.9 years. BMC Musculoskelet Disord 2014; 15: 401.

3. Songur M, Akel I, Karahan S, Kuzgun U, Tümer Y. Prevalence of untreated hip dislocation in Turkish children aged 6 months to 14 years. Acta Orthop Traumatol Turc 2011; 45: 215-220.

4. Mamouri GH, Khatami F, Hamedi AB. Congenital dislocation of the hip in newborns of Mashhad City. The Internet Journal of Pediatrics and Neonatology 2004; 4: 1-5.

5. Laborie LB, Markestad TJ, Davidsen H, et al. Selective ultrasound screening for developmental hip dysplasia: effect on management and late detected cases. A prospective survey during 1991- 2006. Pediatr Radiol 2014; 44: 410-424.

6. Akel I, Songür M, Karahan S, Yilmaz G, Demirkıran HG, Tümer Y. Acetabular index values in healthy Turkish children between 6 months and 8 years of age: a cross-sectional radiological study. Acta Orthop Traumatol Turc 2013; 47: 38-42.

7. Tönnis D. General radiography of the hip joint. In: Tönnis D, editor. Congenital dysplasia and dislocation of the hip. English ed. Heidelberg: Springer-Verlag 1987: 108-113.

8. Mulpuri K, Emily KS, Janice A, et al. What Risk Factors and Characteristics Are Associated With Late Presenting Dislocations of the Hip in Infants? Clin Orthop Relat Res 2016; 474: 1131-1137.

9. Sharpe P, Mulpuri K, Chan A, Cundy PJ. Differences in risk factors between early and late diagnosed developmental dysplasia of the hip. Arch Dis Child Fetal Neonatal Ed 2006; 91: 158-162.

10. Azzopardi T, Van Essen P, Cundy PJ, Tucker G, Chan A. Late diagnosis of developmental dysplasia of the hip: an analysis of risk factors. J Pediatr Orthop B 2011; 20: 1-7.

11. Sarkissian EJ, Sankar WN, Zhu X, Wu CH, Flynn JM. Radiographic follow-up of DDH in infants: are X-rays necessary after a normalized ultrasound? J Pediatr Orthop 2015; 35:551-555.

12. Alexiev VA, Harcke HT, Kumar SJ. Residual dysplasia after successful Pavlik harness treatment: early ultrasound predictors. J Pediatr Orthop 2006; 26: 16-23.

13. Dornacher D, Cakir B, Reichel H, Nelitz M. Early radiological outcome of ultrasound monitoring in infants with developmental dysplasia of the hips. J Pediatr Orthop B 2010; 19: 27-31.

14. Shorter D, Hong T, Osborn DA. Cochrane Review: Screening programs for developmental dysplasia of the hip in newborn infants. Evid Based Child Health 2013; 8: 11-54.

15. Modaressi K, Erschbamer M, Exner GU. Dysplasia of the hip in adolescent patients successfully treated for developmental dysplasia of the hip. J Child Ortho 2011; 5: 261-266.

16. Sink EL, Ricciardi BF, Torre KD, Price CT. Selective ultrasound screening is inadequate to identify patients who present with symptomatic adult acetabular dysplasia. J Child Orthop 2014; 8: 451-455.

17. Kutlu R, Çivi S. The importance of diagnosing developmental dysplasia of the hip in family medicine: a case report. Türk Aile Hek Derg 2007; 11: 140-142.

18. Ceylan MF, Görmeli G, Korkmaz MF, Karataş M, Ekinci Ş, Yoloğlu S. Knowledge and awareness of developmental dysplasia of the hip in medical students in eastern Turkey. Pensee 2014; 76: 168- 172.

19. Rombouts JJ, Rombouts-Godin V. Delayed detection of hip dislocation: is the physician to blame? Pediatrie 1993; 48: 327-334.

Kaynak Göster

1412 840

Arşiv
Sayıdaki Diğer Makaleler

Meningioma of the cavernous sinus

Nitin K. SETHİ, Tomoko IKUİNE, Nicolle STEİNER

Trends and causes of maternal mortality in Eastern province of Turkey

Numan ÇİM, Erkan ELÇİ, Sena SAYAN, Gülhan Güneş ELÇİ, Şerif AKSİN, Recep YILDIZHAN

Effect of postmenopausal strontium ranelate treatment on oxidative stress in rat skin tissue

MEHMET BERKÖZ, Özgün SAĞIR, SERAP YALIN, ÜLKÜ ÇÖMELEKOĞLU, FATMA SÖĞÜT, Pelin EROĞLU

Effect of exercise on erythrocyte osmotic fragility in high fat diet fed rats during intermittent fasting

SEMİH YAŞAR, NİZAMETTİN GÜNBATAR, SEVGİ YÜKSEK, OKAN ARIHAN, GÖKHAN OTO

Survivin expression may affect the neoadjuvant chemotherapy response in breast cancer patients

Zehra ER, HADİCE ELİF PEŞTERELİ, Lema TAVLI, Hakan BOZCUK, GÜLGÜN ERDOĞAN, HACI HASAN ESEN, MEHMET ARTAÇ, LEVENT KORKMAZ, Şeyda GÜNDÜZ, MUSTAFA KARAAĞAÇ, Sinem DEMİRCİOĞLU

Retrospective analysis of patients followed at Van training and research hospital palliative care unit

HAVVA YEŞİL ÇINKIR, Abdullah KAHRAMAN

A young woman with multiple intra cardiac mass, systemic symptoms and stroke

Mohamed Faisal Abdul HAMİD

A case of allergic contact dermatitis due to application of synthetic casting which mimics the manifestation of cellulitis

Tülin TÜRKÖZÜ, Necip GÜVEN

Emergency cesarean in a patient with atrial septal defect

EROL KARAASLAN

Contribution of sonoelastography in the differentiation of benign and malignant breast masses: A comparative analysis on sonographic birads classification

HARUN ARSLAN, Zülküf AKDEMİR, Alpaslan YAVUZ, Necat İSLAMOĞLU, SEBAHATTİN ÇELİK, MESUT ÖZGÖKÇE, ABDUSSAMET BATUR, HÜSEYİN AKDENİZ, Harun Egemen TOLUNAY