Perindopril kullanımı sonrasında serum lityum düzeyinde yükselme: bir olgu bildirimi

Perindopril kullanımı sonrasında serum lityum düzeyinde yükselme: Bir olgu bildirimi Lityum, bipolar bozukluğun akut ve profilaktik tedavisinde kullanılmaktadır. Terapötik kan düzeyi aralığının dar olması sebebiyle, kan konsantrasyon düzeyinin düzenli olarak takibi gerekmektedir. Bu nedenle, ek hastalık veya kombinasyon amacıyla tedaviye eklenen ilaçlarla kan düzeyi yükselebilmekte ve zehirlenme belirtileri gözlenebilmektedir. Özellikle non-steroid antiinflamatuar ilaçlar (NSAİD), tiazid diüretikler, anjiotensin dönüş türücü enzim (ACE) inhibitörleri ile ilaç etkileşimine sık rastlanır. Bu yazıda, bipolar bozukluk tip II tanısıyla 17 yı dır lityum kullanan ve tedavi rejimine hipertansiyon nedeniyle perindopril eklenmesi sonrası lityum kan kon santrasyonu yükselen bir olgu, ilaç etkileşimi bağlamında tartışılmaktadır.

Increase in serum lithium levels induced by perindopril use: a case report

Lithium is widely used for the acute and prophylactic treatment of bipolar disorders. Blood levels of lithium must be monitored regularly because of the low therapeutic index. Combination treatments for comorbid general medical conditions may increase lithium levels and intoxication symptoms can be seen. Interactions particularly with non-steroid anti-inflammatory medicines, thiazide diuretics, angiotensin converting enzyme inhibitors are common. In this case report, increase in serum lithium levels after perindopril prescription for hypertension in a patient with bipolar disorder type II treated with lithium for 17 years was presented.

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