HATİCE HARMANCI, Serap TAYCAN ERDOĞAN, Feryal ÇELİKEL ÇAM

Acute Dystonic Reaction Associated with Increase in Trazodone Dose: A Case Report

Serotonerjik etkili ilaçlar başta depresyon olmak üzere, anksiyete bozuklukları, dürtü kontrol bozuklukları gibi farklı ruhsal hastalıkların tedavisinde kullanılmaktadırlar. Sık görülen yan etkileri arasında, gastrointestinal sistem belirtileri, kilo değişiklikleri, uyku bozuklukları yer almaktadır. İlaçla ortaya çıkan hareket bozuklukları klasik olarak dopaminerjik blokaj yapan ilaçlarla, özellikle de tipik ve atipik antipsikotiklerle ilişkili olarak görülmektedir. Bununla birlikte ekstrapiramidal sistem yan etkilerine serotonerjik ajanların, antiemetiklerin ve opioid agonistlerinin de neden olabildiği görülmektedir. En sık izlenen ekstrapiramidal sistem bulguları akatizi, distoni, parkinsonizm ve tardiv diskinezidir. Bu yazıda 100 mg trazodon almasının ardından akut distonik reaksiyon gelişen ve kas içi antikolinerjik ilaç uygulamasıyla belirtileri geçen bir hasta sunulmaktadır.

Trazodon doz artışı ile ilişkili akut distonik reaksiyon: Bir olgu sunumu

Serotonergic drugs have been used for the treatment of various psychiatric disorders such as anxiety disorders, impulse control disorders and especially depression. Gastrointestinal system symptoms, weight changes and sleep disturbances are commonly observed side effects of serotonergic drugs. Drug-induced movement disorders are classically associated with dopamine receptor blocking agents, most notably typical and atypical antipsychotic medications. However, extrapyramidal side effects can also be seen with serotonergic agents, antiemetics, and opioid agonists. The most common extrapyramidal system symptoms are akathisia, dystonia, parkinsonism, and tardive dyskinesia. We describe a patient who developed an acute dystonic reaction after taking 100 mg trazodone and his symptoms resolved after receiving intra muscular anticholinergic treatment.

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