Zeynep GÜLAY, Tuba ATAY, Meral BİÇMEN, Nuran YULUĞ

Streptococcus pneumoniae suşlarının çeşitli antibakteriyel ajanlara duyarlılığı

Amaç: Başta penisilinler olmak üzere çeşitli antibakteriyel ajanlara dirençli Streptococcus pneumoniae kökenleri tüm dünyada giderek artan sıklıkta bildirilmektedir. Çalışmamızda, Haziran 1999-Ocak 2000 aylan arasındaki alü aylık bir sürede, ikisi kan, biri yara, biri göz sürüntüsü ve 19'u solunum yolu örneklerinden soyutulan 23 S. pneumoniae susunun penisilin, eritromisin, klaritromisin, siprofloksasin, levofloksasin ve trimetoprim-sulfametaksazole (TMP/SMX) duyarlılığı araştırılmıştır. Gereç ve Yöntem: Penisilin duyarlılığının taranması amacıyla oksasilin (l j^g) disk difüzyon yöntemi kullanılmış, oksasilin inhibisyon zonu

Anahtar Kelimeler:

Streptococcus pneumoniae, Antibiyotikler, Penisilin direnci, Mikrobiyal duyarlılık testleri

Susceptibility of Streptococcus pneumoniae strains against various antibacterial agents

Objective: It has been reported that Streptococcus pneumoniae strains resistant to various antibacterial agents especially to penicillins have been increasing all over the world. In our study, a total of 23 S. pneumoniae strains which were isolated from blood (n=2), wound (n=l), eye (n=l) and respiratory system specimens (n=19) dur-ing six months period between June 1999 and Jan 2000 were analyzed for suscepti-bilitiy to penicillin, erythromycin, clarithromycin, ciprofloxacin, levofloxacin and trirhethoprim-sulfamethoxazole (TMP/SMX). Material and Method: Oxacillin (lug) disk diffusion method has been used in or-der to screen penicillin susceptibility. Penicillin, cefotaxime and clarithromycin MIC levels of 10 strains (45%) of which the oxacillin inhibitory zone was found to be <19 mm, were evaluated by the means of E-Test®. Result: Three of these strains were found to be intermediately resistant to penicillin. Percentages of resistance of strains against erythromycin clarithromycin and TMP/SMX, were 13%, 17% and 49% respectively and no resistance against qui-nolone group of antibiotics was observed. Conclusion: Although the number of the strains that has been taken into the study were low, our results demonstrate that the prevalance of penicillin resistance in pneumococcus stains in our region is not high.

Keywords: