HÜLYA GÜNBATAR, Buket ÇİLİNGİR MERMİT, SELAMİ EKİN, Aysel SÜNNETCİOĞLU, AHMET ARISOY, SELVİ AŞKER, BÜNYAMİN SERTOĞULLARINDAN

The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome

Amaç: Obstruktif Uyku Apne Sendromu (OSAS) ile Kardi- yovasküler Hastalıklar (KVH) arasında güçlü bir ilişki var- dır. Kronik intermittan hipoksi, inflamasyon, oksidatif stres ve endotelyal disfonksiyon OSAS ve KVH arasındaki et- yolojik mekanizmaları ortaya çıkarmış olabilir. İnflamas- yon KVH gelişiminde önemli rol oynar. Platelet Lenfosit Oranı (PLO) ve Nötrofil Lenfosit Oranı (NLO) inflamasyo- nu gösteren yeni belirteçlerdir. Bu çalışma PLO ve NLO arasındaki ilişkiyi ve OSAS şiddeti, polisomnografik para- metreler ve PLR arasındaki ilişkiyi araştırmaktadır. Yöntemler: OSAS ön tanısı ile tüm gece polisomnografisi yapılan hastaların çalışmaya dahil edildiği bir kohort çalış- ması planlandı. Hastalar apne hipopne indeksi skorlarına göre sınıflandırıldı. Basit horlama (Grup 1; AHİ 30). Bulgular: 111 hasta çalışmaya dahil edildi. Grup 1, 2 ve 3 te sırasıyla 26, 22 ve 63 hasta vardı. PLO gruplar ara- sında anlamlı düzeyde değişiklik göstermekteydi. Grup 1de 87,12, Grup2de 103,6, Grup 3te 112,5 idi (p < 0.05). PLO ile NLO, AHİ, oksi jen desaturasyon indeksi, ortalama ve minimum oksi jen saturasyon değeri arasında anlamlı derecede ilişki vardı (p

Obstruktif uyku apne sendromunda platelet lenfosit oranı ve nötrofil lenfosit oranı ilişkisi

Objective: There is a strong relationship between ob- structive sleep apnea syndrome (OSAS) and cardiovas- cular disease (CVD). Chronic intermittent hypoxia, inflam- mation, oxidative stress, and endothelial dysfunction may create etiologic mechanisms, connection between OSAS to CVD. Inflammation play an important role in the devel- opment of CVD. Platelet- Lymphocyte Ratio (PLR) and Neutrophil-lymphocyte Ratio (NLR) are new biomarkers showing inflammation. This study was designed to inves- tigate the association between PLR, NLR and relationship between severity of OSAS, polysomnographic param- eters and PLR. Methods: This was a cohort study in which patients who had undergone a full night polysomnography for diagnosis of OSA were recruited. Patients were divided according to their apnea hypopnea index (AHI) scores into OSAS neg- ative simple snoring (Group 1; AHI <5 times/hours), mild (Group 2; AHI: 5-15), moderate (Group 3; AHI:15-30), and severe OSAS (Group 4; AHI >30) groups. Results: A total of 111 patients were included in this study. There were 26, 22 and 63 patients in Groups 1, 2 and 3, respectively. PLR were significantly different be- tween groups (Group 1: 87.12, Group 2: 103.6, Group 3: 112.5, p < 0.05). PLR were significantly correlated with NLR, AHI, oxygen desaturation index, average and mini- mum O2 saturation values (p < 0.05). Multiple regression analysis demonstrated that PLR is an independent pre- dictor of CVD. PLR cut-off value for demonstrating the presence of CVD is higher than 86.03. Conclusion: In the light of these findings, PLR is strongly associated with the severity of OSAS. PLR might be used as a biomarker to predict CVD in OSAS patients.

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