Esma BİLGİ AKKOYUN, GÖKMEN ZARARSIZ, Hafize SAV, Fatma ÖZAKKAŞ, NURİ KİRAZ

Distribution of Candida species isolated from blood cultures in a university hospital

Amaç: Kandidemi, nozokomiyal kan dolaşımı enfeksi- yonları arasında dördüncü sırada yer almaktadır. İnvaziv kandidiyazda Candida albicans halen en sık tanımlanan patojen olsa da, albicans dışı kandida türlerine bağlı en- feksiyonlarda dramatik artış dikkati çekmektedir bu du- rum, klinik uygulamadaki değişimleri yansıtmaktadır. Bu çalışmanın temel amacı kandidemi etkeni Candida türle- rinin hastanemizdeki dağılımını belirleyerek hastane en- feksiyonlarının önlenmesine katkıda bulunmaktır. Yöntemler: Retrospektif (2013-2014) bu çalışmada kan kültürlerinden izole edilen Candida türlerinin epidemiyo- lojik, klinik ve mikrobiyolojik karakteristikleri bildirilmiştir. Bulgular: Toplam 200 Candida spp türü %38 C. albicans, %24,5 C. parapsilosis, %16,5 C. tropicalis, %13 C. glab- rata, %3 C. krusei, %2 C. sake, %1 C. lusitaniae, %0,5 C. guilliermondii olarak tanımlanmıştır. Tanımlanan Candida türleri en yüksek oranla (103/200; %51,5) yoğun bakım ünitesinde saptanmıştır. Sonuç: Candida infeksiyonları için risk teşkil eden hasta popülasyonunun artmasına paralel olarak, türlerin tanım- lanması ve etkin tedavi protokollerinin geliştirilmesi için epidemiyolojik çalışmaların yapılması gerekmektedir.

Bir üniversite hastanesinde kan kültürlerinden izole edilen Candida türlerinin dağılımı

Objective: Candidemia is the fourth most common infec- tion among nosocomial blood circulation infections. Al- though Candida albicans is the most frequently identified species in invasive candidiasis, incidence of non-albicans Candida species were increased especially among criti- cally ill patients. This reflects the changes in clinical prac- tice. The main objective of the present study is to deter- mine the distribution of the Candida species that causes candidemia in our hospital and contributes to the preven- tion of nosocomial infections. Methods: In a retrospective study (2013-2014) on candi- demia, various Candida species isolated from blood cul- tures were evaluated and their epidemiological, clinical, and microbiological characteristics were determined. Results: A total of 200 species of Candida were iden- tified and the distribution was as follows: 38% C. albi- cans, 24.5% C. parapsilosis, 16.5% C. tropicalis, 13% C. glabrata, 3% C. krusei, 2% C. sake, 1% C. lusitaniae, 0.5% C. guilliermondii. The highest amounts of (103/200; 51.5%) of Candida species were identified at the adult intensive care unit. Conclusion: Parallel to the increase in the patient popu- lation that is as risk for Candida infections, epidemiologi- cal studies should be made to identify the species and develop effective treatment protocols.

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