Adolesan İdiyopatik Skolyozda Serum Selenyum, Çinko ve Bakır Düzeylerinin Araştırılması

Amaç: Bu çalışmada adolesanlardaki idiyopatik skolyozun etiyolojisinde serum selenium, çinko ve bakır düzeylerininaraştırılması amaçlanmıştır.Yöntemler: Çalışmaya 10-17 yaş arası idiyopatik skolyozu olan 44 hasta alınmıştır. Hastaların vertebra eğrilikdereceleri 280 ile 820 arasında değişiklik göstermiştir. İdiopatik skolyozlu hastalar vertebra eğrilik derecelerine göre450 altı (grup 1) ve 450 üstü (grup 2) eğrilikler olarak 2 gruba ayrılmıştır. Çocuklarda tam kan sayımı, serumselenyum, çinko, bakır düzeyleri çalışılmıştır.Bulgular: İdiyopatik skolyozlu hastaların 33’ü (%75) kızdır. İdiopatik skolyozlu hastalar ve kontrol grupları arasındaserum çinko ve bakır düzeylerinde istatistiksel olarak anlamlı farklılık görülmemiştir (p>0,05). İdiyopatik skolyozluhastalarda kontrol grubuna göre serum selenyum düzeyi düşüktür ve istatistiksel olarak anlamlı bulunmuştur(p<0,05). Hastaların eğrilik dereceleri ve demografik özelliklerine bakıldığında, grup 2’nin yaş ortalaması, grup 1’egöre istatistiksel anlamlı olarak daha yüksektir (p<0,05). İdiopatik skolyozlu hastaların eğrilik derecelerine göreserum selenyum, çinko ve bakır düzeyleri karşılaştırıldığında grup 1 ile grup 2 arasında laboratuvar ölçümlerindeistatistiksel olarak anlamlı bir fark görülmemiştir (p> 0,05).Sonuç: Eser elementlerden olan selenyum idiopatik skolyozlu hastaların serumunda daha düşük bulunmuştur.Çalışmamız bu konuda Türkiye’de yapılan ilk çalışmalardan biridir ve daha geniş çaplı çalışmalara ihtiyaç olduğudüşünülmüştür.

Anahtar Kelimeler:

idiyopatik skolyoz, selenyum, çinko, bakır

Investigation of Serum Levels of Selenium, Zinc, and Copper in Adolescents with Idiopathic Scoliosis

Objective: The purpose of this study was to investigate the serum levels of selenium, zinc and copper on the etiologyof idiopathic scoliosis in adolescents.Methods: Forty four idiopathic scoliosis patients between 10 and 17 years of age were considered in this study. Thevertebra curvature degrees of the patients were between 28° and 82°. The idiopathic scoliosis patients were assignedto two groups based on their vertebra curvature degrees. Curvature degree of 45° and lower was labeled as group 1and curvature of upper 45° was labeled as group 2. Total blood count, serum levels of selenium, zinc and copper werestudied.Results: Thirty three of the idiopathic scoliosis patients (75%) were female. There was no statistically significantdifference in serum zinc and copper levels between idiopathic scoliosis patients and the control group (p> 0.05).Serum selenium levels in idiopathic scoliosis patients were lower than that of the control group and the differencewas statistically significant (p< 0.05). In terms of vertebra curvature degree and demographic characteristics of thepatients, group 2 age average was significantly higher than that of the group 1 (p< 0.05). When serum selenium, zinc,and copper levels were compared based on the vertebra curvature degrees of the IS patients, no statisticallysignificant difference was observed between group 1 and 2 in laboratory measurements (p > 0.05).Conclusion: Among the measured trace elements, selenium was lower in the serum of the IS patients. This is the firststudy in Turkey that we know of about this subject and we think that further studies are needed.

Keywords:

idiopathic scoliosis, selenium, zinc, copper,

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