Gökhan AÇMAZ, Ahmet TAYYAR, Mehmet TAYYAR, Gökalp ÖNER

The investigation of relationship between preeclampsia and antiphospholipid antibody syndrome

Amaç. Bu çalışmanın amacı preeklampsi ve antifosfolipid antikor sendromu arasında ilişki olupolmadığının belirlenmesidir. Yöntem. Çalışmaya 20-40 hafta arasındaki toplam 116 gebekatılmıştır. Preeklampsi tanısı alan 63 hasta çalışma grubumuzu oluşturmuştur. Kontrol grubunasağlıklı, normotensif ve sistemik hastalığı olmayan 53 gebe dahil edilmiştir. Çalışma ve kontrolgrubunda bulunan gönüllülerden antifosfolipid antikoru olarak lupus antikoagülan, anti kardiolipinantikorları (IG G ve M) ve antifosfatidilserin antikorları (IG G ve M) çalışılmıştır. Bulgular.Preeklampsi ve konrol grubu arasında antifosfolipid antikor sendromu açısından istatistiksel olarakanlamlı farklılık saptanmamıştır ancak bu antikorlar kontrol grubu ile karşılaştırıldığında,preeklamptik grupta iki kat daha yüksek olarak saptanmıştır. (preeklampside %22,2 kontrolgrubunda %11,3) P=0,193. Sonuç. Bu çalışmada preeklampsi ve antifosfolipid antikor sendromuarasında ilişki gösterilememiştir ancak preeklamptik hastalarda antifosfolipid antikorlarının yüksekolarak saptanması daha geniş çaplı ve çalışmalara gereksinim olduğunu göstermektedir.

Preeklampsi ve antif osf olip id antikor sendromu arasındaki ilişkinin incelenmesi

Aim. The aim of this study was evaluate the relationship between preeclampsia andantiphospholipid antibodies. Methods. A total of 116 pregnant women between 20th and 40thweeks of gestation admitted to our department were investigated. 63 of them were allocated ourpreeclampsia group and 53 of them were allocated our control group. Lupus anticoagulant, anti- cardiolipin antibodies (IG G ve M) and antiphosphatidylserine antibodies (IG G ve M) weremeasured. Results. There was no statistical significance between preeclampsia and control groupfor antiphospholipid antibodies but these were two times higher in preeclamptic group comparedto control group. (22.2% in preeclampsia, 11.3% in control group p=0.193). Conclusions. In anunselected population we were not able to demonstrate an association between preeclampsia andantiphospholipid antibody syndrome but antiphospholipid antibody ratio elevated in women withpreeclampsia. These findings show that, there is a need for large scale studies.

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