Bülent SARAÇ, Zekeriya ÖZTEMÜR, İhsan BAĞCIVAN, Hayati ÖZTÜRK, Okay BULUT, Gündüz TEZEREN, Nedim DURMUŞ

Akut spinal kord yaralanması sonrasi erken cerrahi dekompresyonun korpus kavernozum ve motor fonksiyon üzerine olan etkilerinin araştırılması

Amaç. Akut spinal kord yaralanması sonrasi erken cerrahi dekompresyonun korpus kavernozumve motor fonksiyon üzerine olan etkilerinin araştırılması. Yöntem. Yirmi bir adet 9-12 aylık YeniZelanda tipi, erişkin erkek tavşan kullanıldı. Denekler kontrol grubu (n=5), laminektomi grubu(n=6), 15 saniye kompresyon grubu (n=5) ve 60 sn kompresyon grubu (n=5) olmak üzere 4 grubaayrıldı. Laminektomi grubuna sadece laminektomi işlemi yapıldı. Kompresyon gruplarına 60 gkapama gücü olan anevrizma klipsi ile 15 ve 60 saniye kompresyon uygulandı. 1, 3, 5 ve 7. günlerModifiye Tarlov skoru ile motor değerlendirme yapıldı. 7 gün sonunda bütün denekler sakrifiyeedilerek spinal kordlarından histopatolojik çalışma ile beraber izole korpus kavernozumdokularından in vitro organ banyosunda kasılma ve gevşeme yanıtları incelendi. Bulgular.Modifiye Tarlov skoruna bakıldığında gruplar arası fark anlamlı bulundu (p0,05). Sonuç. Akutspinal kord yaralanmasında erken cerrahi dekompresyonun etkinliğini araştırdığımız bu model ilespinal kord yaralanmasında seksüel disfonksiyonunun tedavisinde kullanılması düşünülen ilaçlarınin vitro ortamda ayrıntılı olarak araştırılması mümkün olabilir. Akut spinal kord yaralanmasındaerken cerrahi dekompresyon motor iyileşme yönünden faydalı olabilir ve korpus kavernozumfonksiyonları açısından olumlu etkiler yapabilir. Ayrıca, akut spinal kord yaralanması geçirenhastalarda erektil disfonksiyon fosfodiesteraz tip V inhibitörleri ile çözülebilir.

Evaluation of corp us cavernosum and motor f unction af ter early surgical decompressssion on acute spinal cord inj ury

Aim. Evaluation of corpus cavernosum and motor function after early surgical decompressssion onacute spinal cord injury. Method. We initiated the study with 21 New Zealand male rabbit. Theanimals were assigned to four groups which were sham group (n=6), laminectomy group (n=5), 15seconds compression group (n=5) and 60 seconds compression group (n=5). Fifteen seconds or 60seconds compression applied to compression group in 60 gram compression force with aneurysmclips. We evaluated motor system with modified Tarlov score at 1st, 3rd, 5th and 7th days of cordinjury. All rabbits are sacrificed after 7 day postoperatively. Histopathological evaluations aremade on spinal cord and in vitro relaxation and contraction tests were performed on urinarybladder and corpus cavernosum tissues in tissue baths. Results. There was significant differencebetween all groups according modified Tarlov score (p

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