Figen ÖZTÜRK, Mehmet TAYYAR, Tuncay ÖZGÜN, Ahmet TAYYAR, Özgüç ALTUN, Ahter Tanay TAYYAR

Sıçanlarda oluşturulan deneysel uterin horn adezyon modelinde düşük molekül ağırlıklı heparin ile oktreotidin etkileri

Amaç. Düşük molekül ağırlıklı heparinin postoperatif adezyon önleyici etkinliği daha önceyapılan çeşitli çalışmalarda öne sürülmüştür. Yine Growth hormon üzerinden etki ederek Insulinlike growth faktör inhibisyonuyla inflamatuar hücrelerin maturasyon ve migrasyonunu inhibe edenoktreotidin adezyon önleyici etkisi yapılan bazı araştırmalarda gösterilmiştir.Bu çalışmadaadezyon gelişiminin farklı basamaklarına etki eden düşük moleküler ağırlıklı heparin veoktreotidin tek başlarına ve kombine kullanımları halinde adezyon oluşumunu önleyici etkilerininkarşılaştırılması amaçlanmaktadır. Yöntem. Çalışmada ağırlığı 250-300 gr arasında değişen 40adet Wistar-Albino tipi dişi sıçan kullanıldı. Sıçanlar randomize olarak 10ar sıçanlık grup halindekontrol ve 3 adet çalışma gruplarına ayrıldı. Adezyon modeli oluşturulduktan sonra kontrol grubudışındaki diğer 3 gruba düşük moleküler ağırlıklı heparin, oktreotid ve düşük moleküler ağırlıklıheparin ile oktreotid birlikte 14 gün süreyle uygulandı.14 gün sonra sıçanlar letal doz pentobarbitalile öldürüldükten sonra orta hat insizyon ile laparotomi yapılarak adezyon gelişimi değerlendirildi.Bulgular. Makroskopik olarak adezyon şiddeti 3 çalışma grubunda kontrol grubuna göre dahadüşük bulundu (p

The affect of low molecular weight heparin and octreotide in an experimental uterine horn adhesion model

Aim. Previous studies proposed that low molecular weight heparin reduces postoperative adhesionformation. Octreotide reduces the maturation and migration of inflammatory cells by inhibitinginsulin like growth factor via growth hormone. Some studies showed that octreotide also reducespostoperative adhesion formation. Low molecular weight heparin and octreotide influencedifferent stages of adhesion formation. The aim of this study was to compare the effect of lowmolecular weight heparin and octreotide on postoperative adhesion formation either alone or incombination. Methods. The study included 40 Wistar Albino rats weighing between 250-300 g.They were randomised to three study and one control groups each containing 10 rats. Afterperforming an adhesion model except for the control group, low molecular weight heparin,octreotide and low molecular weight heparin plus octreotide groups received the agents for14days. The animals were sacrificed by lethal dose pentobarbital at the end of 14 days and a mid-linelaparatomy was carried out and abdominal cavity was inspected for the presence of adhesion.Results. In macroscopic evaluation, adhesion severity in the 3 study groups were lower than thecontrol group (p

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