Deniz TORUN, Salih KOZAN, Murat DEDE, Müfit Cemal YENEN, Şefik GÜRAN, Zehra Dilşad ÇOBAN, Uğur KESKİN

Predisposition of papillary thyroid carcinoma in a family dignosed as hereditary breast and ovarian cancer syndrome

Herediter meme over kanser sendromu, erken dönemde tanı alan ailesel tip meme ve/veya overkanseri ile karakterizedir. Ailelerde prostat ve pankreas kanserine yatkınlık görülebilir. Yazımızdaherediter meme-over kanser sendromu tanısı almış bir aile sunulmakta vebu ailede sık gözlenenpapiller tip tiroid kanserini oluşturabilecek nedenler tartışılmaktadır. Ailede BRCA 1 ve BRCA 2genlerinin belli bölgelerinde mutasyon gösterilmemiştir. Ancak klinik olarak meme over kansersendromu tanısı alan aile literatüre göre papiller tiroid kanserine yatkınlıkla tanımlanan tekörnektir. Burada tanımlanan farklı tümör tiplerinde etkilenen ortak bir mekanizma olduğudüşünülebilir. Sonuç olarak, papiller tiroid kansere yatkınlığı olan herediter meme-over kansersendromu tanısı almış nadir ailelerde etkilenen yolakları bulmak için daha fazla araştırmaya gerekvardır.

Herediter meme over kanser sendrom tanısı almış ailede tiroid papiller kanser birlikteliği

Hereditary breast and ovarian cancer syndrome is characterized by the familial type of breastand/or ovarian cancers diagnosed at early onset. In these families, predisposition to prostate andpancreas cancers can be seen. Here a family who had hereditary breast and ovarian cancersyndrome was presented and we also discussed the possible mechanisms in the predisposition ofpapillar type thyroid cancer which is common in this family. No BRCA 1 and BRCA 2 mutationhad been observed in certain loci in this family. Due to the literature findings, our family is thesole example which has clinically hereditary breast and ovarian cancer syndrome diagnosis withthyroid papillary carcinoma predisposition.Here, there may be a common mechanism affected inthese different tumors. So, further studies are necessary to find out affected pathways in patientshaving hereditary type breast and ovarian cancer who has also predispositionto papillary thyroidcarcinoma.

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