Engin ONAN, Hikmet AKKIZ, Macit Umran SANDIKCI, Oğuz ÜSKÜDAR, Agah Bahadır ÖZTÜRK

Hepatoselüler karsinomda serum mikroRNA-122'nin önemi

Amaç: Bu çalışmanın amacı, hepatoselüler karsinomda dolaşımdaki mikroRNA-122'nin (miR-122) biyobelirteç olarak potansiyelini araştırmaktır. Gereç ve Yöntem: Bu çalışmada, dolaşımdaki miR-122 seviyeleri, hepatoselüler karsinomun farklı klinik evreleri olan hastalarda gerçek zamanlı polimeraz zincir reaksiyonu ile ölçülmüştür. Ayrıca, bu veriler ile serum miR-122 seviyeleri arasındaki korelasyonu gözlemlemek için diğer laboratuvar ve klinik veriler de değerlendirilmiştir. Bulgular: Hepatoselüler karsinom hastalarında serum miR-122 seviyeleri kontrol grubuna göre anlamlı olarak yüksek bulundu. (medyan miR-122 (min. - maks.); hastalar: 0,0104 (0-0,262); kontroller: 0,00187 (0-0,100), p

Anahtar Kelimeler:

Hepatoselüler karsinom, serum microRNA-122., microRNA-122

Importance of circulating microRNA-122 for hepatocellular carcinoma

Purpose: The main purpose of our study is to research the potential of circulating microRNA-122 (miR-122)as a marker for hepatocellular carcinoma. Materials and Methods: Circulating miR-122 levels were measured by real-time polymerase chain reaction in patients with varied stages of hepatocellular carcinoma. In addition, various other laboratory and clinical data of the participants were evaluated in order to observe the correlation between these data and serum miR-122 levels. Results: Serum miR-122 levels were found significantly higher in hepatocellular carcinoma patients compared to the control group. (median miR-122 (min. – max.); patients: 0.0104 (0-0.262); controls: 0.00187 (0-0.100), p

Keywords:

Hepatocellular carcinoma, microRNA-122, circulating microRNA-122,

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