Mustafa Yaprak, Gül İlhan, Feyyaz Bay, Ümran Gezici Güneş, Faruk Turgut

Akut böbrek yetmezliği ile prezente olan lenfoma olgusu

Kanser hastalarında da akut böbrek yetmezliği (ABY), normal popülasyonda olduğu gibi prerenal, renal ve postrenal nedenlere bağlı olarak ortaya çıkmaktadır. Böbreğe tümör infiltrasyonu genellikle yaygın değildir. Fakat akut lösemi veya lenfoma gibi hızlı büyüyen hematolojik malignitelerde tümör tutulumuna bağlı böbrek fonksiyonları bozulabilmektedir. Burada akut böbrek yetmezliği ile başvuran ve daha sonra lenf nodu biyopsisi ile B hücreli Nonhodgkin lenfoma tanısı alan bir olgu sunulmuştur. Tümör infiltrasyonuna bağlı ABY gelişmesi nadir olmakla birlikte, akut böbrek yetmezliği gelişimi açısından risk faktörü bulunmayan olgularda lösemik veya lenfomatöz infiltrasyon düşünülmelidir.

A case of lymphoma presented with acute renal failure

Acute renal failure (ARF) in patients with malignancy occurs due to causes such as prerenal, renal and post renal as in normal population. Tumor infiltration of kidneys is usually uncommon. However, renal function may be impaired in fast-growing hematological malignancies such as acute leukemia or lymphoma, depending on tumor involvement. Herein, we presented a case of ARF and later diagnosed as B-cell Non-Hodgkin’s lymphoma. 54-year-old male patient was admitted due to ARF. Although development of ARF due to tumor infiltration is rare, in cases who did not have risk factors for development of ARF, leukemic or lymphomatous infiltration should be considered.

Keywords:

Acute renal failure, lymphoma, Infiltration,

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1. Humphreys BD, Soiffer RJ, Magee CC. Renal failure associated with cancer and its treatment: an update. J Am Soc Nephrol. 2005;16:151-61.
2. Simsek S, Oen AL, Comans EF, v d Hoeven JJ, Zijlstra J. Acute renal failure due to non-Hodgkin lymphoma infiltration of the kidneys detected by ultrasonography and confirmed by positron emission tomography. Clin Nephrol. 2003;59:383-7.
3. Lommatzsch SE, Bellizzi AM, Cathro HP, Rosner MH. Acute renal failure caused by renal infiltration by hematolymphoid malignancy. Ann Diagn Pathol. 2006;10:230-4.
4. Coggins CH. Renal failure in lymphoma. Kidney Int. 1980;17:847-55.
5. Xiao JC, Walz-Mattmüller R, Ruck P, Horny HP, Kaiserling E. Renal involvement in myeloproliferative and lymphoproliferative disorders. A study of autopsy cases. Gen Diagn Pathol. 1997;142:147-53.
6. Rıchmond J, Sherman RS, Dıamond HD, Craver LF. Renal lesions associated with malignant lymphomas. Am J Med. 1962;32:184-207.
7. Obrador GT, Price B, O'Meara Y, Salant DJ. Acute renal failure due to lymphomatous infiltration of the kidneys. J Am Soc Nephrol. 1997;8:1348-54.
8. Mitome T, Furuya K, Imano M, Osaka K, Yokomizo Y, Hayashi N et al. Bilateral renal lymphoma: rapid recovery from an acute kidney injury after open renal biopsy.Clin Case Rep. 2015;4:5-8.
9. Freedman A. Follicular lymphoma: 2014 update on diagnosis and management. Am J Hematol. 2014;89:429-36.
10. Magee CC. Overview of renal disease associated with malignancy In: UpToDate. Curhan GC (eds). UpToDate, Waltham, MA, 2015.
11. Corapi KM, Chen JL, Balk EM, Gordon CE. Bleeding complications of native kidney biopsy: a systematic review and meta-analysis. Am J Kidney Dis. 2012;60:62-73.
12. Hande KR, Garrow GC. Acute tumor lysis syndrome in patients with high-grade non-Hodgkin's lymphoma. Am J Med. 1993;94:133-9.