Prematür adrenarş ve günümüzdeki önemi

Adrenal androjen üretiminin aktivasyonuna bağlı olarak, kızlarda 8, erkeklerde 9 yaş öncesi aksiller kıllanmanın da eşlik edebileceği, pubik kıllanmanın erken oluşumu “prematür adrenarş” olarak adlandırılır. Kızlar, erkeklerden bundan çok daha sık olarak etkilenir ve kesin tanısı, pubik kıllanmanın diğer olası nedenlerinin elimine edilmesi ile konulur. Prematür adrenarş, spesifik bir endokrin tedavi gerektirmeyen, selim bir durum gibi görünmekle birlikte; özellikle son yıllarda üzerinde durulan ve burada detaylı olarak tartışılan metabolik ve endokrin etkileri nedeni ile önem taşımaktadır. Bu nedenle bu hastaların, puberte ve sonrasına kadar yakın izlenmesi gereklidir.

Anahtar Kelimeler:

Buluğ, erken gelişmiş, Adrenarş, fizyopatoloji, Gonad hastalıkları, Tanı, ayırıcı, Kalp damar hastalıkları, Buluğ çağı

Premature adrenarche and its importance

Apperance of pubic hair, with or without aksillary hair development, due to the activation of adrenal androgen secretion before eight years of age in girls and nine years in boys, is named as premature adrenarche. It occurs more frequently in girls than in boys and its definite diagnosis is basicly depend on eliminating the other reasons causing occurrence of pubic hair. Although PA looks like a benign condition, not necessitating a specific treatment, it gained more importance recently because of its metabolic and endocrine effects, which were discussed in detail here. These patients should be followed-up to post-puberty and adulthood because of these potential effects.

Keywords:

Puberty, Precocious, Adrenarche, physiopathology, Gonadal Disorders, Diagnosis, Differential, Cardiovascular Diseases, Puberty,

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