Ergin ARSLAN, Sevinç ŞAHİN, Seyhan KARAÇAVUŞ, Murat SÜHER, Ahmet BAL, Selda SEÇKİN, Mesut SİPAHİ, Kasım ÇAĞLAYAN

YOZGAT BÖLGESİNDE DİFERANSİYE TİROİD KANSERİ NEDENİYLE TAKİP EDİLEN HASTALARIN KLİNİK VE DEMOGRAFİK ÖZELLİKLERİ

Amaç: Bu çalışmanın amacı, Yozgat bölgesindeki diferansiye tiroid karsinomlu (DTK) hastaların de- mografik ve klinik özelliklerini tespit etmektir. Gereç ve Yöntemler: 2011-2014 yılları arasında Bozok Üniversitesi Araştırma ve Uygulama Hastanesinde DTK tanısıyla takip edilen 62si kadın, 13ü erkek toplam 75 hasta retrospektif olarak değerlendirildi. Hastaların histopatolojik ve klinik özellikleri yaş, cinsiyet, tümör tipi ve metastaz açısından birbirleri ile karşılaştırıldı. Bulgular: Hastaların yaş ortalaması 46.3±13.9 olup 16-79 yaş arasında dağılım göstermekteydi. Diferansiye tiroid karsinomunda kadın/erkek oranı 4,8/1 olarak bulundu. Ortalama tanı yaşı kadın hastalarda 45,2±14,2 iken erkek hastalarda 49.5±5.1 idi. Tümör tipleri içinde % 78,7 ile en yaygın papiller karsinom, ikinci sıklıkta % 13,3 ile papiller karsinom foliküler varyant, üçüncü sıklıkta % 5,3 ile folliküler karsinom tespit edilmiştir. Bununla birlikte uzak metastaz oranı folliküler karsinomda daha fazlaydı. Sonuç: Tüm DTKlu hastalar içinde en yaygın görüleni papiller karsinomdu. Kadın hasta sayısı erkek hasta sayısından tüm kanser tiplerinde daha yüksekti. Papiller veya folliküler tiroid karsinomu ile tanı yaşı arasında istatistiksel olarak anlamlı farklılık yoktu. Uzak metastaz oranı folliküler karsi- nomda papiller karsinoma göre daha yüksek bulundu.

Clinical and Demographic Characteristics of the Patients Followed due to Differentiated Thyroid Carcinoma in Yozgat Region

ABSTRACT Objective: The purpose of this study was to determine clinical and demographic characteristics of the patients with differentiated thyroid carcinoma (DTC) in Yozgat region. Materials and Methods: Seventy five patients, consisted of 62 females and 13 males, followed due to DTC between 2011 and 2014 in Bozok University Research and Practise Hospital were ret- rospectively evaluated. Their clinical and hystopathological characteristics were compared with each other for age, gender, tumor type and metastasis of the disease. Results: The mean age of patients was 46.3±13.9 years (range 16-79 years). The ratio of female to male was found 4,7/1 in DTC. The mean age of diagnosis was 45,2±14,2 for females, while 49.5±5.1 for males. Papillary carcinoma was determined as the most common type of tumor with 78,7 % , the second common type was papillary carcinoma follicular variant with 13,3 % , the thirth common type was follicular carcinoma with 5,3 % in all tumor types. However, distant me- tastasis ratio was more in follicular carcinoma. Conclusion: Papillary thyroid cancer was most common in all patients with DTC. In all types of DTC female patients were more than males. There was not any statistically significant difference between the mean age of diagnosis for follicular thyroid cancer and for papillary thyroid cancer. Distant metastasis ratio was found to be higher in follicular thyroid cancer than papillary thyroid cancer.

PDF

___

1. Moeller LC, Führer D. Thyroid hormone, thyroid hormone receptors, and cancer: a clinical perspective. Endocr Relat Cancer. 2013;20(2):19-29.
2. Carling T, Udelsman R. Thyroid tumors. In: DeVita VT, Hellman S, Rosenberg SA., Cancer: Principles and Practice of Oncology. 7th Edition, Philadelphia: Lippincott Williams & Wilkins, 2005. p. 1502-19.
3. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):6990.
4. Starnes HF, Brooks DC, Pinkus GS, Brooks JR. Surgery for thyroid carcinoma. Cancer. 1985;55(6):1376-81.
5. Merhy J, Driscoll HK, Leidy JW, Chertow BS. Increasing incidence and characteristics of differentiated thyroid cancer in Huntington, West Virginia. Thyroid. 2001;11(11):1063-9.
6. Burgess JR. Temporal trends for thyroid carcinoma in Australia: an increasing incidence of papillary thyroid carcinoma (1982-1997). Thyroid. 2002;12(2):141-9.
7. Muro-Cacho CA, Ku NN. Tumors of the thyroid gland: histologic and cytologic features-part 1. Cancer Control. 2000;7(3):276-87.
8. Kumar V. Diseases of the endocrine system. In: Kumar V, Cotran R, Robbins SL., Basic Pathology, 5th edition, WB Saunders: Philadelphia, Pennsylvania. 1992. p. 643-80.
9. Franssila KO, Ackerman LV, Brown CL, Hedinger CE. Follicular carcinoma. Semin Diagn Pathol. 1985;2(2):101-22.
10. Leung AK, Chow SM, Law SC. Clinical features and outcome of the tall cell variant of papillary thyroid carcinoma. Laryngoscope. 2008;118(1):32-8.
11. Elboğa U, Doğan N, Kalender E, Çelen YZ, Yılmaz M, Demir HD, et al. Demographical analysis of the patients received radioiodine therapy for the differentiated thyroid carcinoma in our clinic. Gaziantep Med J. 2012; 18(1): 27-30.
12. Schlumberger M, Challeton C, De Vathaire F, Travagli JP, Gardet P, Lumbroso JD, et al. Radioactive iodine treatment and external radiotherapy for lung and bone metastases from thyroid carcinoma. J Nucl Med. 1996(2);37:598605.
13. Zettinig G, Fueger BJ, Passler C, Kaserer K, Pirich C, Dudczak R, et al. Long-term follow-up of patients with bone metastases from differentiated thyroid carcinoma: surgery or conventional therapy? Clin Endocrinol (Oxf). 2002;56 (1):37782.
14. Haq M, Harmer C. Differentiated thyroid carcinoma with distant metastases at presentation: prognostic factors and outcome. Clin Endocrinol (Oxf). 2005;63(1):87-93.
15. Sawka AM, Brierley JD, Ezzat S, Goldstein DP. Managing newly diagnosed thyroid cancer. CMAJ. 2014;186(4):269-75.