UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM

Uyku yoksunluğu ve bozulmuş uyku kalitesi bireyin yaşantısını olumsuz yönde etkileyen ve aynızamanda ilişkili olduğu klinik antiteler nedeni ile de morbiditesi yüksek olan bir durumdur. Hipertansiyon, obezite, inme ve kalp hastalığı riskini artırabileceği için popülasyonda genel mortaliteyide etkilemektedir. Son yıllarda yapılan çalışmalar, uyku bozuklukları ve gastrointestinal hastalıklar arasında kuvvetli bir ilişki olduğunu vurgulamaktadır. Tümör nekroz faktörü, interlökin-1 veinterlökin-6 gibi proinflamatuar sitokinlerin artışı, uyku bozukluğuyla ilişkilendirilmektedir. Busitokinler; gastroözofageal reflü hastalığı, inflamatuar bağırsak hastalığı, karaciğer bozuklukları ve kolorektal kanser gibi bazı gastrointestinal sistem hastalıklarında da artış göstermektedir.Hekimlerin ve özellikle de ilgili uzmanların, hastaların hayat kalitesini yükseltebilmek ve daha iyibakım sağlayabilmek için uyku bozuklukları ve gastrointestinal hastalıklar arasındaki ilişkinin farkında olmaları gerekmektedir. Bu makalede, uyku bozuklukları ve bazı gastrointestinal hastalıklararasındaki ilişki gözden geçirilecektir.

Sleep Disorders and the Gastrointestinal System

Sleep deprivation and impaired sleep quality is a condition that affects the individual’s experience negatively and at the same time has a high morbidity due to the associated clinical conditions. It can increase risk of hypertension, obesity, stroke and heart disease and also affects general mortality in the population. Recent studies have emphasized a strong association between sleep disorders and gastrointestinal disorders. The increase in proinflammatory cytokines, such as tumor necrosis factor, interleukin-1 and interleukin-6, is associated with sleep disturbances. These cytokines are increased also in gastroesophageal reflux disease, inflammatory bowel disease, liver disorders and colorectal cancer. Physicians, and in particular related specialists, should to be aware of the relationship between sleep disorders and gastrointestinal disorders in order to improve the quality of life of patients and provide better care. In this article, the

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