HİPERTANSİYONUN HOMOSİSTEİNEMİ SEVİYELERİYLE İLİŞKİSİ

Amaç: Hipertansiyon dünya genelinde yaygın bir rahatsızlık olup, kardiyovasküler hastalıklarda bağımsız bir risk faktörüdür. Birçok çalışma artmış homosisteinemi seviyeleriyle hipertansiyonun benzer dağılım gösterdiğini ve her ikisinin de kardiyovasküler olayların artışıyla ilişkili olduğunu da göstermiştir. Bununla birlikte çelişkili sonuçlar da mevcuttur. Çalışmamızın amacı hipertansiyonla hiperhomosisteinemi arasındaki ilişkiyi araştırmaktır.Gereç ve Yöntemler: Hipertansiyonu olan 30 hasta ve tansiyonu normal olan 30 olgu çalışmamız kapsamına alınarak; homosistein, folik asit, B12 vitamini ve B6 vitamini serum seviyeleri ölçüldü. Aynı zamanda, metilentetrahidrofolat redüktaz (MTHF) C677T ve MTHFR 1298 polimorfizmleri de araştırıldı.Bulgular: Arteriyel tansiyonu normal olan grupta 16 erkek ve 14 kadın olmak üzere 30 olgu vardı. Yaşları 36-72 arasında değişmekte ortalama yaş 49.8±11.3 yıl idi. Hipertansif grupta ise 17 erkek ve 13 kadın olmak üzere toplam 30 olgu vardı. Yaşları 34-71 arasında değişmekte ortalama yaş 51.1±13.4 yıl idi. Hipertansif grupta kadınlarda homosisteinemi seviyesi ortalama 12.8 ± 3.2 µmol/L, erkeklerdeyse 14.5 ± 4.3 µmol/L idi. Tansiyonu normal olan grupta ise kadınlarda ortalama homosisteinemi seviyesi 9.8 ±2.4 µmol/L, erkeklerdeyse 12.3 ± 2.9 µmol/L idi. Homosisteinemi seviyeleri hipertansif grupta ve her iki grupta da erkeklerde anlamlı olarak yüksek bulundu (p

The Relationship of Hypertension with Homocysteinemia Levels

Aim: Hypertension is a common disease throughout the world; it is an independent risk factor for cardiovascular disease. Most studies showed similar distribution of increased homocysteinemia level and hypertension, and both are related to increased risk of cardiovascular disorders. However, conflicting results have been reported. The aim of this study was to investigate the association of the hypertension with hyperhomocysteinemia. Material and Methods: A total of 30 hypertensive patients and 30 normotensive subjects were included in the study. Serum levels of homocysteine, folic acid, vitamin B12 and vitamin B6 were measured. Also methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR 1298 polymorphisms were investigated. Results: The healthy group was composed of 16 males and 14 females, ranging in age between 36 and 72 years with a mean age of 49.8±11.3 years. In the hypertensive group, there were 17 males and 13 females, ranging in age between 34 and 71 years with a mean age of 51.1±13.4 years. In hypertensive group, the mean homocysteinemia level was 12.8 ± 3.2 µmol/L in females and 14.5 ± 4.3 µmol/L in males, whereas the mean homocysteinemia level was 9.8 ±2.4 µmol/L in females and 12.3 ± 2.9 µmol/L in males of healthy group. Homocysteinemia levels were found to be significantly higher in hypertensive group and males in both groups (p

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