Ahmet AKÇA¹, Tamer BAYSAL¹, Zeki TAŞDEMIR², Ahmet AKÇA MD, Safiye Tokgöz ÖZAL MD, Zeki TAŞDEMIR MD

TRAVMATİK OLMAYAN TALAR OSTEOKONDRAL DEFEKTDE İSKEMİK ETYOLOJİNİN DEĞERLENDİRİLMESİ

Amaç: Bu çalışmada travmatik olmayan osteokondral defektler ile serum ortalama trombosit hacmi arasındaki ilişkiyi incelemeyi amaçladıkGereç ve yöntemler: Ayak bileği MR çekimi yapılmış hastaları retrospektif olarak taradık. Talar osteokondral defekti (OKD) olan 15 hasta ile OKD'si olmayan 11 hasta çalışmaya dahil edildi. OKD'si olan hastalardan travma anamnezş olanlar çalışmaya dahil edilmedi. Total tombosit sayısı (TS), ortalama trombosit hacmi (OTH) ve trombosit dağılım genişliğini (TDG )içeren laboratuar testleri hasta kayıt sisteminden elde edildi. Bu değerler hasta ve kontrol grup arasında karşılaştırıldı.Bulgular: TS, OTH ve TDG değerlerinini hepsi iki grupta da normal sınırlarda olup iki grup arasında anlamlı farklılık saptanmadı.Sonuç: Travmatik olmayan talar OkD'lerde değişik etyolojik sebepler tanımlanmıştır. Bunlardan biri olan iskemi travmatik olmayan OKD'nin nedenlerinden biri olmayabilir.

Evaluation of Ischemic Etiology in Non Traumatic Talar Ostechondral Defect

Aim: We aimed in this study to evaluate the relationship between serum mean platelet volume and non traumatic talar ostechondral defects .Materials and methods: We retropectively analyzed the patients who underwent ankle MRI. 15 patients with talar osteochondral defect, 11 patients with no talar osteochondral defects were included in the study. The patients with osteochondral defect who had history of trauma were excluded from the study. Laboratory tests including serum mean platelet volume (MPV), platelet distribution width (PDW) and total platelet (PLT) count compared between the patients and control group.Results: MPV, PDW and total platelet count were all in normal range both in patients and control group. We revealed no significant difference between the patients and control group Conclusion: Different etiologic factors are described in the non traumatic talar OCDs. Ischemia, which is the one of the estimated factors, may be less likely to predispose to non traumatic talar OCD.

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1. Zandecki M, Genevieve F, Gerard J, Godon A. Spurious counts and spurious results on haematology analysers: a review. Part I: platelets. Int J Lab Hematol. 2007 Feb;29(1):4- 20.
2. Mayda-Domaç F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis. 2010 Jan; 19 (1) : 66-72.
3. Bath P, Algert C, Chapman N, Neal B; PROGRESS Collaborative Group. Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease. Stroke. 2004 Mar;35(3):622-6.
4. Turfan M, Erdogan E, Ertas G, Duran M, Murat SN, Celik E et al. Usefulness of mean platelet volume for predicting stroke risk in atrial fibrillation patients. Blood Coagul Fibrinolysis. 2013 Jan;24(1):55-8.
5. Tavil Y, Sen N, Yazici H, Turfan M, Hizal F, Cengel A et al. Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients. Platelets. 2010;21(5):368- 72.
6. Sansanayudh N, Anothaisintawee T, Muntham D, McEvoy M, Attia J, Thakkinstian A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol. 2014 Aug 20;175(3):433-40.
7. Khode V, Sindhur J, Kanbur D, Ruikar K, Nallulwar S. Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: A case control study. J Cardiovasc Dis Res. 2012 Oct;3(4):272-5. ja
8. Berndt AL, Harty M. Transchondral fractures (osteochondritis dissecans) of the talus. J Bone Joint Surg [Am] 1959;41-A:988- 1020.
9. Davidson AM, Steele HD, MacKenzie DA, Penny JA. A review of twenty- one cases of transchondral fracture of the talus. J Trauma 1967;7:378-415.
10. Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J. 2001 Sep; 22(17):1561-71.
11. Otunctemur A, Bozkurt M, Besiroglu H, Polat EC, Ozcan L, Ozbek E. Erectile Dysfunction Is Positively Correlated with Mean Platelet Volume and Platelet Count, but Not with Eosinophil Count in Peripheral Blood. Urol J. 2015 Nov 14;12(5):2347-52.
12. Coskun A, Yavasoglu I, Sargin G, Ok IM, Bircan M, Avcil M et al. The role of mean platelet volume in patients with non-specific abdominal pain in an emergency department. Prz Gastroenterol. 2015;10(3):156-9.
13. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: Its relationship to bleeding time, thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res. 1983;32:443-60.
14. Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CA. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982; 50: 509-19.
15. Schoene N W. Design Criteria: tests used to assess platelet function. Am J Clin Nutr 1997; 65 (Supplement): 1665- 8S.
16. Park Y, Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets. 2002 Aug-Sep;13(5-6):301-6.
17. Verhagen RA, Struijs PA, Bossuyt PM, van Dijk CN. Systematic review of treatment strategies for osteochondral defects of the talar dome. Foot Ankle Clin. 2003 Jun;8(2):233- 42, viii-ix.
18. Chen HS, Chen SC, Wang HJ, Lin SY, Kang JH. Ultrasonographic Findings and Clinical Characteristics of Two Patients With Talar Osteochondritis Dissecans. Journal of Medical Ultrasound. 2011 Jun;19(2: 47-51)
19. Schachter AK, Chen AL, Reddy PD, Tejwani NC. Osteochondral lesions of the talus. J Am Acad Orthop Surg 2005 May;13(3):152-8.