BOYUNDA LOKALİZE DARİER HASTALIĞI
51 yaşındaki kadın hasta 6-7 yıldır artıp azalarak giden boyun yerleşimli lezyonlarla başvurdu. Dermatolojik muayenesinde boyun laterallerinde yoğunlaşan kahverengi milimetrik papülleri ve el tırnaklarında V şeklinde çentiklenmeleri mevcuttu. Histopatolojik inceleme Darier hastalığı ile uyumlu olarak geldi
Darier's Disease Localized On The Neck
A 51-year-old woman attended with asymptomatic lesions on her neck which had been present for 7 years. On dermatological examination multiple brown milimetric keratotic papules were observed on the lateral sides of neck and V-shaped nicks were observed on the nails of her hand. Histopathological examination of the lesions were consistent with Darier disease.Darier disease is an autosomal dominant skin disorder characterized by keratotic papules, focal loss of adhesion and abnormal keratinization. Several clinical variants of Darier disease have been described. Localized flexural distribution of lesions in Darier disease is uncommon. We report a sporadic case of Darier disease in which the lesions were strictly localized to the neck. Physicians should be aware of such atypical localizations and should consider the diagnosis Darier disease along with more common clinical conditions with flexural localization, such as HaileyHailey disease and Grover disease.
___
- 1. Messer G. Dermatomyositis and Other Autoimmune Disorders. Braun Falco's Dermatology. Ed. Burgdorf WHC, Plewig G, Wolff HH, Landthaler M. 3. Baskı. Italya, Springer Medizin Verlag Heidelberg, 2009; 731-849.
- 2. Goldsmith LA, Baden HP. Darier-White disease (Keratosis follicularis) and acrokeratosis verruciformis. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, Fitzpatrick TB, eds. Dermatology in general medicine, 5th ed. New York: Mc Graw-Hill, 1999: 614-9.
- 3. Sprowson AP, Jeffery SLA, Black MJM: Darier's disease, an unusual problem and solutıon. J Hand Surg (Br). 2004; 29B: 3: 291-293.
- 4. Sehgal VN, Srivastava G. Darier's (Darier-White) disease/ keratosis follicularis Int J Dermatol. 2005; 44(3):184-192.
- 5. Tavadıa S, Mortımer E, Munro CS. Genetic epidemiology of Darier's disease: a population study in the west of Scotland. Br J Dermatol. 2002; 146:107-109.
- 6. Zeglaoui F, Zaraa I, Fazaa B, Houimli S, El Fekih N, Ezzine N, et al. Dyskeratosis follicularis disease: case reports and review of the literature. J Eur Acad Dermatol Venereol. 2005; 19:114-117.
- 7. Jalil AA, Zaina RB, van der Waal I. Darier disease: a case report. Br J Oral Maxillofac Surg. 2005; 43:336-338.