Probiyotik Bakterilerin Aflatoksin M1 Detoksifikasyonu Üzerine Etkisi

Aflatoksin, mutajenik, karsinojenik, hepatotoksik ve immünosupresif özellikte, insan ve hayvan sağlığına olumsuz etkiler gösteren güçlü bir mikotoksindir. Aflatoksin M1 ise sıklıkla süt ve süt ürünlerinde bulunan kuvvetli bir toksindir. Süt ve süt ürünlerinin her yaşta birey tarafından sıklıkla tüketildiği göz önüne alındığında süt ve sütteki yüksek AFM1 düzeyi önemli bir halk sağlığı riski oluşturmaktadır. Günümüzde, aflatoksinin etkisiz hale getirilmesinde kullanılan fiziksel ve kimyasal yöntemlerin etkin olmaması nedeniyle güvenilir detoksifikasyon yöntemlerine gereksinme duyulmaktadır. Literatürde, yararlı mikroorganizmalar olarak bilinen probiyotik bakterilerin aflatoksin M1i bağlayarak bu toksini detoksifiye etme yeteneğinin olduğu çeşitli çalışmalarda bildirilmektedir ve probiyotik bakteriler biyolojik olması nedeniyle de umut verici görülmektedir. Bu derlemede, probiyotik bakterilerin aflatoksin M1 detoksifikasyonu üzerine etkisinin incelendiği çalışmalar değerlendirilmiştir.

The Effect of Probiotic Bacteria on Aflatoxin M1 Detoxification

Aflatoxins are strong mycotoxins with mutagenic, carcinogenic, hepatotoxic and immunosuppressive properties that can cause harmful effects on animal and human health. Aflatoxin M1 (AFM1) is also a potent toxic compound frequently found in milk and dairy products.A high AFM1 incidence in milk and milk products creates an important public health risk due to the fact that milk and milk products are consumed widely by all age groups. Since physical and chemical methods that are used to deactivate aflatoxin are not effective enough, safe detoxification methods are needed. Probiotic bacteria which are known as beneficial microorganisms show a potential for biological control. In literature, several studieshave reported that probiotic bacteria have detoxification ability through binding of AFM1. This review evaluates detoxification effects of probiotic bacteria on aflatoxin M1.

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