Mantar ve Kanser: Olası Adjuvan Tedavi Ajanı Olarak Mantar

Mantar uzun yıllardan beri kanser hastalarının geleneksel tedavisinde kullanılmaktadır. Son yıllarda giderek artan araştırmalar da özellikle bazı mantar türlerinin kanser üzerine olumlu etkileri olduğunu kanıtlar niteliktedir. Mantar türleri antikanser etkilerini özellikle immünomodülatör özellikleri sayesinde göstermektedir. Mantarın bu özelliğini sağlayan bileşenlerin başında polisakkaritler gelirken özellikle ?-D-glukanın daha ön plana çıktığı bildirilmiştir. Bu makalede, mantar ekstraktlarının kanser üzerine etkilerinin gösterildiği in vitro, in vivo ve kesitsel çalışmaların yanı sıra, mantar tüketiminin kanser üzerine etkilerinin gösterildiği müdahale çalışmaları da derlenerek mantarın kanser hastalarında adjuvan tedavi ajanı olarak kullanılıp kullanılamayacağı konusu tartışılmıştır.

Mushrooms and Cancer: Mushroom as Possible Adjuvant Treatment Agent

Mushroom is used in conventional treatment of cancer patients for many years. In recent years, numerous studies present growing evidence that some species of mushroom have particularly beneficial effects on cancer. Anticancer effects of mushrooms are attributed especially to their immunomodulatory properties. Polysaccharides are the components providing this feature of mushroom. In particular, ?-D-glucan has been reported to gain more importance as a polysaccharide. In this article, in addition to in vitro, in vivo and crosssectional studies that demonstrate beneficial effects of mushroom on cancer, intervention studies on mushroom consumption were reviewed and the use of mushroom as an adjuvant therapy in cancer patients is discussed.

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