Olcay HİSAR, M. Sıtkı ARAS, Aras Şükriye HİSAR, Telat YANIK

Balık kan karbondioksitinin taşınması ve atılmasında karbonik anhidraz izoenzimlerinin fonksiyonları

Balıklarda, kan karbondioksitinin $(CO_2)$ taşınması ve atılımı omurgalılardakine benzer şekilde meydana gelir. $CO_2$, konsantrasyon gradiyenti doğrultusunda dokulardan eritrositlere diftlze olur ve eritrositlerde karbonik anhidraz enzimi (CA) tarafından $HCO_3^- ve H^+$'a katalizlenir. Meydana gelen protonlar hemoglobin tarafından tamponl.anırken bikarbonat anyonlarının birçoğu, plazma klorür iyonunun hücre içine girişi ile hücre: dışına pasif olarak taşınırlar. Böylece dokulardan solungaçlara taşınan total $CO_2$'in çoğu plazma HCCV'ı olarak taşınmış olur. Solungaçların kılcal damarlarında ise bu siklüs tersine işler. Bu derlemede, CO2'in taşınması ve atılmasında iki önemli bileşen olan eritrosit ve solungaç CA izoenzimlerinin fonksiyonları anlatılmıştır.

The functions of carbonic anhydrase isozymes at fish blood carbon dioxide transport and excretion

In fish, blood carbon dioxide $(CO_2)$ transport and excretion follows the similar strategy as in vertebrates. COz from the tissues diffuses down its concentration gradient into the erythrocytes where it becomes catalyzed to $HCO_3^- and H^+$ by carbonic anhydrase (CA). The protons generated are largely buffered by hemoglobin whereas most of the bicarbonate anions are passively transported out of the cell in exchange for plasma chloride. Most of tbe total CO2 transported from the tissues to the gill is thus carried as plasma $HCO_3^-$ At the capillaries of the gill, the cycle is essentially reversed. In this review, it was explained that the functions of two important components, erythrocyte and gill CA, of these blood $CO_2$ transport and excretion processes.

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