Hücre adezyon molekülleri

Organizmada hücreler arası uyum, yaşamın devamlılığının temel kuralını oluşturmaktadır. Bu uyum, çeşitli hücre içi ve hücre dışı faktörler yardımıyla gerçekleştirilmektedir. Bu faktörlerin bir grubunu hücre adezyon molekülleri oluşturur. Hücre adezyon molekülleri; integrinler, selektinler, immunoglobulin süper ailesi ve kaderinler olmak üzere 4 grupta toplanır. Prenatal ve postnatal dönemlerde hücrede meydana gelen gelişim aşamaları; hücresel proliferasyon, göç, farklılaşma ve olgunlaşmada görev alırlar. Hücre hareketlerinin organizasyonunda, immun ve inflamatuvar yanıtın ortaya çıkmasında da oldukça önemli rolleri vardır. Bu derlemede adezyon moleküllerinin yapısal özellikleri ve bu özelliklere bağlı olarak hücreler arası etkileşimdeki fonksiyonları değerlendirilmektedir.

Cell adhesion molecules

The harmony between the cells in an organism is one of the main principles for their survival. This harmonic position is determined by various intracellular and extracellular factors. The adhesion molecules are categorised into 4 groups as; integrins, selectins, Ig super family and cadherins. They are also effective for carrying out the cell functions in addition to their roles in cellular proliferation, migration, differentiation and maturation at prenatal and postnatal developmental stages. In particular, the organisation of cellular actions and the maintenance of immune and inflammatory responses have very important roles. In the present review; the structure of adhesion molecules and the functions they gain depending on these features are criticised.

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Abbas AK., Lichtman AH., (eds). 2003. Maturation, activation and regulation of lymphocytes. In Cellular and Molecular Immunology. 5th ed. London: WB Saunder Company, 127–241.
Akoğlu E. 1996. Glomerulo nefritlerde T hücrelerinin, sitokinlerin ve büyüme faktörlerinin rolü. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 3, 92–96.
Alattia JR., Tong KI., Takeichi M., Ikura M. 2002. Cadherins. Methods Mol. Biol., 172, 199–210.
Alon R., Etzioni A. 2003. LAD-III, a novel group of leukocyte integrin activation deficiencies. Trends Immunol., 24, 561– 566.
Atabekoğlu CS., Engin Y., Üstün Y., Aytaç R. 2002. Üreme fizyolojisi ve adhezyon molekülleri. A.Ü. Tıp Fakültesi Mecmuası, 55, 85–92.
Aydıntuğ O. 1998. Hücre adezyon molekülleri. Güncel Gastroenteroloji, 2, 11, 128–134.
Aytekin C., İkincioğulları A. 2004. Lökosit adezyonu ve lökosit adezyon defekti sendromları. Astım Allerji İmmunoloji, 2, 157–166.
Balaian LB., Moehler T. 2000. The human neural cell adhesion molecule L1 functions as a costimulatory molecule in T-cell activation. Eur. J. Immunol., 30, 938–943.
Barlow JZ., Huntley GW. 2000. Developmentally regulated expression of Thy–1 in structures of mouse sensorymotor system. J. Comp. Neurol., 421, 215–233.
Bauer EM., Perks P., Lightman SL., Shanks N. 2001. Are adhesion molecules involved in stres induced changes in lymphocyte distribution? Life Sci., 69, 1167–1179.
Bazzoni G. 2003. The JAM family of junctional adhesion molecules. Curr. Opin. Cell. Biol., 15, 525–530.
Behar E., Chao NJ., Hirake DD. 1996. Polymorphism of adhesion molecule CD31 and its role in acute graft versus host disease. N. Engl. J. Med., 334, 286–291.
Behrens J. 1994. Cadherins as determinants of tissue morphology and supressors of invasion. Acta. Anat., 149, 165–169.
Brand M., Derner G., Boeke K. 1997. Antirejection prophylaxis by blocking selectin dependent cell adhesion after rat allogenic and xenogenic transplantation. Eur. J. Cardiothorac. Surg., 12, 781–786.
Brevetti G., Schiano V., Chiariello M. 2006. Cellular adhesion molecules and peripheral arterial disease. Vasc. Med., 11, 39–47.
Cremer H., Chazal G. 2000. PSA-NCAM an important regulator of hippocampal plasticity. Int. J. Dev. Neurosci., 18, 213–220.
Crockard AD., Boylan MT. 1998. Corticosteroids effects on neutrophil adhesion molecules. Int. J. Clin. Lab. Res., 28, 110–115.
Crossin KL., Krushel AL. 2000. Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily. Dev. Dyn., 218, 260–279.
Deeths MJ., Mescher MF. 1999. ICAM–1 and B7–1 provide similar but distinct costimulation for CD8+T cells while CD4+T cells are poorly costimulated by ICAM 1. Eur. J. Immunol., 29, 45–53.
Demyanenko G., Tsai AY., Maness PF. 1999. Abnormalities in neuronal process extension, hippocampal development and the ventricular system of knockout mice. J. Neurosci., 19, 4907–4920.
Deveci U., Ayaz S., Ayaz A., Elevli M. 2002. Sepsisli çocuklarda serum interselüler adezyon molekülü-1 düzeyleri. Çocuk Sağlığı ve Hastalıkları Dergisi, 45, 162–168.
Ehrhardt C., Kneuer C., Bakowsky U. 2004. Selectins-an emerging target for drug deliver. Pharmacol. Res., 56, 527–549.
Erdem F. and Alper D. 1997. Adhezyon molekülleri. T. Klin. J. Med. Sci., 17, 75–77.
Ergüler G., Demir N., Demir R. 2002. Adezyon moleküllerinin yapısal özellikleri ve fonksiyonları., T. Klin. J. Med. Sci., 22, 313–327.
Etzioni A. 1996. Adhesion molecules their role in health and disease. Ped. Res., 39, 191–198.
Fassbender K., Mossner R., Motsch L. 1995. Circulating selectin and immunoglobulin type adhesion molecules in acute ischemic stroke. J. Allergy Clin. Immunol., 26, 1361–1364.
Feldmann M. 1996. Intercellular adhesion molecules. Eds; Roitt I., Brastaffl J., Male D. Immunology, Barcelona.
Foster CA. 1996. VCAM–1/4 Integrin adhesion pathway: Therapeutic target for allergic inflammatory disorders. J. Allergy Clin. Immunol., 98, 270–277.
Freemont AJ. 1995. The significance of adhesion molecules in diagnostic histopathology. Current. Diagn. Path., 2, 101–110.
Frenette PS., Denisa D., Wagner DD. 1996. Adhesion molecules-part II. N. Engl. J. Med., 335, 43–45.
Fukuda T., Kawano H., Ohyama K., Li HP., Takeda Y., Oohira A., Kawamura K. 1997. Immunohistochemical localization of neuroCAM and L1 in the formation of thalamocortical pathway of developing rats. J. Comp. Neurol., 382, 141–152.
Gearing AJH., Newman W. 1993. Circulating adhesion molecules in disease. Immunol. Today, 14, 506–512.
Güç D. 2004. Adezyon molekülleri. Astım Allerji İmmünoloji, 2, 95–102.
Haznedaroğlu IC., Benekli M. 1998. Adezyon molekülleri. Turkish J. Hematol. and Oncology, 4, 252–254.
Hemler ME. 1990. VLA proteins in the integrin family: Structures, funcftions, and their role on leukocytes. Annu. Rev. Immunol., 8, 365–400.
Hoffman KB., Murray BA., Lynch G., Munirathinam S., Bahr BA. 2001. Delayed and isoform spesific effect of NMDA exposure on neural cell adhesion molecules in hippocampus. Neuroscience Res., 39, 167–173.
Hogervorst F., Kuikman I., Kesel AG., Sonenberg A. 1991. Molecular cloning of the human a6 integrin subunit: Alternative splicing of a6 mRNA and chromosomal localization of the a6 and b4 genes. Eur. J. Biochem., 199, 425–433.
Horstmann LL., Jimenez JJ., Ahn YS. 2004. Endothelial microparticles as markers of endothelial dysfunction. Front. Biosci., 9, 1118–1135.
Huo Y., Ley K. 2001. Adhesion molecules and atherogenesis. Acta. Physiol. Scand., 173, 35–43.
Hynes RO. 1992. Integrins versatility modulation and signalling in cell adhesion. Cell, 69, 11–25.
Ilan N., Madri JA. 2003. PECAM–1: Old friend new partners. Curr. Opin. Cell. Biol., 15, 515–524.
Jung U., Ley K. 1999. Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin. J. Immunol., 162, 6755–6762.
Kansas GS. 1996. Selectins and their ligands: Current concepts and controversies. Blood, 88, 3259–3287.
Kasper C., Rasmussen H. 2000. Structural basis of cell-cell adhesion by NCAM. Nat. Struct. Biol., 7, 389–393.
Kemler R. 1992. Classical cadherins. Stem Cell. Biol., 3, 149–155.
Lee SW. 1996. H-cadherin a novel growth inhibitory function and diminished expression in human breast cancer. Nature Med., 2, 776–782.
Lubetzki C., Charles P. 2000. Pivotal role of axonal adhesion molecules in central nervous system myelination. Neurol. Neurochir. Pol., 34, 41–44.
Luscinskas FW., Lawler J. 1994. Integrins as dynamic regulators of vascular function. Faseb. J., 8, 929–938.
Mackay CR., Imhof BA. 1993. Cell adhesion in the immune system. Immunol. Today, 14, 99–102.
Malik AB., Lo SK. 1996. Vascular endothelial adhesion molecules and tissue inflammation. Pharmacol. Res., 48, 213– 229.
McDowall A., Inwald D., Leitinger B. 2003. A novel form of integrin dysfunction involving β1, β2, and β3 integrins. J. Clin. Invest., 111, 51–60.
Mousa SA. 2004. Cell adhesion molecules: Potential therapeutic and diagnostic implications. Methods. Mol. Med., 93, 157–174.
Murohara T., Delyani JA., Albelda SM., Lefer AM. 1996. Blockade of platelet endothelial cell adhesion molecule–1 protects against myocardial ischemia and reperfusion injury in cats. J. Immunol., 156, 3550–3557.
Nagafuchi A., Shirayoshi Y., Okazaki K. 1987. Transformation of cell adhesion properties by exogeneously introduced E-cadherin cDNA. Nature, 329, 341–343.
Nathke IS., Hinck L., Swedlow JR., Rapkoff J., Nelson WJ. 1994. Defining interactionsand distributions of cadherin and catenin complexes in polarized epithelial cells. J. Cell Biol., 125, 1341– 1352.
Newman PJ., Berndt MC., Gorski J. 1990. PECAM–1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science, 247, 1219–1222.
Oleszewski M. and Gutwein P. 2000. Characterization of the L1-neurocan binding site implications for L1-L1 homophilic binding. J. Biol. Chem., 275, 34478–34485.
Önder MR., Nalbantgil I. 1997. Hücre adezyon molekülleri endotel ve fonksiyonları. Bristol-Myers Squibb.
Pathre P., Arregui C., Wampler T., Kue I., Leung TC., Lilien J., Balsamo J. 2001. PTP1B regulates neurite extension mediated by cellcell and cell-matrix adhesion molecules. J. Neurosci. Res., 15, 143–150.
Peach RJ., Hollenbaugh D., Stamenkovic I., Aruffo A. 1993. Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J. Cell Biol., 122, 257–264.
Pilewski H., Albelda SM. 1993. Adhesion molecules in the lung. Am. Rev. Respir. Dis., 148, 31–37.
Rahman J., Meilsp J. 1997. Dynamic exercise leads an to increase in circulating ICAM–1 further evidence per adrenergic modullation of cell adhesion. Brain Benav. Immun., 11, 343–351.
Ronn LC., Berezin V. 2000. The neural cell adhesion molecule in synaptic plasticity and ageing. Int. J. Dev. Neurosci., 18, 193–199.
Roos D., Law SKA. 2001. Hematologically important mutations leukocyte adhesion deficiency. Blood Cells Mol. Dis., 27, 1000–1004.
Rudloff S., Kunz C. 1995. Variations of intercellular adhesion molecules. Eur. J. Med. Res., 1, 171–172.
Ruoslahti E., Pierschbacher MD. 1987. New perspective in cell adhesion: RGD and integrins. Science, 238, 491–497.
Saygılı Ö., Gültekin F. 1999. Hücre adezyon molekülleri. T. Klin. Tıp. Bil., 19, 362– 365.
Schmid-Schonbein GW. 2006. Analysis of inflammation. Annu. Rev. Biomed. Eng., 8, 93 131.
Shyu KG., Chang H., Lin CC. 1997. Serum levels of intercellular adhesion molecule–1 and E-selectin in patients with ischemic stroke. J. Neurol., 244, 90–93.
Sims TN., Dustin ML. 2002. The immunological synapse: İntegrins take the stage. Immunol. Rev., 186, 100–117.
Somay G., Bulkan M., Mısırlı H. 2007. Akut serebral iskemili hastalarda E-selektin ve Hs Crp’nin serum seviyeleri. Türk Serebrovasküler Hastalıklar Dergisi, 13, 41–49.
Takeichi M. 1990. Cadherins: A molecular family important in selective cell-cell adhesion. Ann. Rev. Biochem., 59, 237– 252.
Takeichi M. 1991. Cadherin cell adhesion receptors as a morphogenetic regulator. Science, 251, 1451–1455.
Tanaka S., Sakata Y., Morimoto K., Tambe Y., Watanabe Y., Honda G., Tabata M., Oshima T., Masuda T., Umezawa T., Shimada M., Nagakura N., Kamisako W., Kashiwadw Y., Ikeshiro Y. 2001. Influence of naturel and synthetic compounds on cell surface expression of cell adhesion molecules ICAM–1 and VCAM–1. Planta Med., 67–69.
Terekeci H., Şahan B., Top C. 2008. Hücre adezyon molekülleri. Nobel Med., 10, 1–7.
Vieren M., Le Trong H., Wood CL., Moore PF., St John T., Staunton DE., Gallatin WM. 1995. A novel leukointegrin alpha-beta 2, binds preferentially to ICAM–3. Immunity, 3, 683–690.
Wijnhoven BPL., Dinjens WN., Pignatelli M. 2000. E-cadherin/catenin cell-cell adhesion complex and human cancer. Br. J. Surg., 87, 992–1005.
Wiley J., Sons K. 1996. Cell and molecular biology. Gerald Corp., Canada.
Wilson GA. 1996. Cell adhesion molecules fundamental facts. R&D Systems.