Levent KAYRIN, Umut KÖKBAŞ, Kezban KARTLAŞMIŞ

Kanser Metabolizması ve Otofaji

Otofaji hasarlı veya gereksiz protein ve organellerin temizlenmesi ve besinsel strese yanıt olarak enerji kaynaklarını dengelemek amacıyla hücrenin kendini parçalama sürecidir. Apoptozis mekanizması hasarlı olan tümör hücrelerinde otofaji, hücrenin sağ-kalım süresini uzatmaktadır. Bununla birlikte otofaji, tümör oluşumunun erken evrelerinde tümör baskılanmasını sağlayabilir. Bu durumda otofajinin uyarılması kanserin önlenmesinde yararlı olabilir. Bu derlemede otofajinin önemi, normal dokulara kıyasla tümör dokusuna olan bağımlılığına ve tümör oluşumunda metabolizmaya olan etkisi tartışılarak genel bir bakış açısı ile sunulmuştur.

Cancer Metabolism and Autophagy

Autophagy is the process of self-disruption of the cell in order to clean up damaged or unnecessary proteins and organelle and to balance energy resources in response to nutritional stress. In tumor cells that are damaged by the mechanism of apoptosis, autophagy prolongs the survival time of the cell. However, autophagy may provide tumor suppression in the early stages of tumor formation. In this case, induction of autophagia may be beneficial in the prevention of cancer. In this review, the autophagy is presented with a general view on the effect of autophagy on the tumor tissue dependence compared to normal tissues and on the metabolism in tumor formation

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