Derya SAĞLAM, Süleyman DURMAZ, HÜSEYİN KILIÇ, Mustafa Altay ATALAY, Barış Derya ERÇAL, Şule ŞARLI, Duygu PERÇİN

Kan kültürlerinden izole edilen escherıchıa colı suşlarında genişlemiş spektrumlu beta-laktamaz sıklığı ve antibiyotik direnç paternleri

Genişlemiş spektrumlu beta-laktamaz (GSBL) direnci plazmidler aracılığıyla türler arasında aktarılabilmekte, hastane lerde salgınlar oluşturabilmekte, tedavilerin yetersiz kalmasına ve hastaların hastanede yatış sürelerinin uzamasına ve morta lite oranlarının yükselmesine yol açabilmektedir. Bu çalışmada, 2009 yılında kan kültürlerinden izole edilen Escherichia coli suşlarının GSBL üretme sıklığı ve GSBL üreten ve üretmeyen suşlar arasında antibiyotik duyarlılığı farklılıklarının saptan ması amaçlanmıştır. İzole edilen 95 E.coli suşunun 37’sinde (% 39) GSBL varlığı saptanmıştır. GSBL oluşturma kadınlardan elde edilen suşlarda erkeklerden, çocuklardan elde edilenlerde erişkinlerden, yoğun bakımdan elde edilenlerde servislerden elde edilenlere göre daha yüksek bulunmuştur (p

The frequency of extended-spectrum beta-lactamases and antibiotic resistance patterns in escherichia coli strains ısolated from blood cultures

Extended-spectrum beta-lactamase (ESBL) resistance can be transferred by plasmids between species and related to epidemics in hospitals, inadequate treatment, prolonged hospital stay and increased mortality rates. The aim of the present study was to determine the frequency of ESBL production in E.coli strains isolated from blood cultures and the diffences in antibiotic susceptibility of ESBL producing and nonproducing strains. ESBL production was determined in 37 (39 %) of 95 E.coli strains. ESBL production was found higher in strains isolated from women comparing with men, in strains isolated from children comparing with adults, in strains isolated from intensive care units comparing with clinics. Imipenem, meropenem and ertapenem were found to be effective in all strains. The rates of resistance to antibiotics that used in treatment were found significiantly higher in ESBL positive E.coli strains when compared with ESBL negative E.coli strains.

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