Ayla GÜNLEMEZ, Ulukol Betül BULUT, Şükrü CİN, Derya AYSEV

Streptokoksik farenjitli çocuklarda benzatin penisilin G, penisilin V ve azitromisin tedavilerinin karşılaştırılması

Bu çalışma streptokoksik farenjitli çocuklarda benzatin penisilin C, penisilin V ve azitromisin tedavilerinin etkinliği ve emniyetini karşılaştırmak amacıyla yapılmıştır. Boğaz kültüründe beta hemolitik streptokok üreyen, yaşları 7-77 arasındaki 797 çocuk çalışmaya alınmıştır. Hastalardan 85'i benzatin penisilin C (BPC), 57'si penisilin V (PV) ve 55'ı azitromisin ile tedavi edilmiştir. Hastalar tedaviyi izleyen 10. ve 20. günlerde klinik ve bakteriyolojik olarak değerlendirilmiştir. Tüm tedavi gruplarında yeterli klinik yanıt saptanmıştır. Bakteriyolojik eradikasyon oranı ilk kontrolde BPC grubunda % 95.6, PV ve azitromisin grubunda % 97.8 olarak saptanmıştır, ikinci kontrolde ise rekürrens oranı BPC grubunda % 3.1, PV ve azitromisin grubunda %2.3'dür. Hiç bir hastada ciddi yan etki görülmemiştir.

The comparison between benzathine penicillin G, penicillin V and azithromycin in the treatment of streptococcal pharyngitis in children

The efficacy and safety of benzathine penicillin C (BPC), penicillin V (PV) and azithromycin in the treatment of Streptococcal pharyngitis in pediatric patients were compared in this study. One hundred and ninety-seven patients aged between 1-17 years presented with symptoms of pharyngitis, who had positive throat culture-positive for beta hemolytic streptococci were enrolled. Among 197 culture-positive patients, 85 were treated by BPG, 57 were treated by PV and 55 were treated by azithromycin. Patients were evaluated for clinical and bacteriological improvement W days and 20 days following the initiation of treatment. Satisfactory clinical responses were recorded in all of the treatment groups. Throat culture -negativity rate was 95.6% in BPC treatment group, 97.8% in both PV and azithromycin treatment groups at the first visit. Recurrence rate was found 3.1 % in BPC, 2.3% in both PV and azithromycin treatment groups at the second visit. No serious adverse effect has seen in patients.

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