Semih KANDİLCİ, Lale KARAAĞAÇLIOĞLU, Fügen ÇOKÇA

Rekombinant hepatit B aşısı ile temas öncesi profilakside serokonversiyon oranlarının araştırılması

Çalışmamızda 36 Diş Hekimliği Fakültesi öğrencisine, 0-1-2-12 şe¬ması ile intramüsküler yoldan rekombinant hepatit B aşısı yapıldı. Her aşı dozundan bir ay sonra kan örneği alınarak koruyucu antikor dü¬zeyleri araştırıldı. Birinci, ikinci ve üçüncü aşıları takiben elde edilen serokonversiyon oranlan sırasıyla % 36, % 88 ve % 100 idi.

Seroconversion rates with recombinant hepatitis B vaccine in preexposure prophylaxis

in our study 36 students of Faculty of Dental Surgery were given recombinant hepatitis B vaccine intramuscularly by 0-1-2-12 schedule. After one month of each vaccine dose, blood samples were taken and tested for protective antibody levels. After the first, second and third vaccine injections, the seroconversion rates were 36 %, 88 % and 100 %, respectively.

PDF

___

1. Ahman L Back E Bensch K Olcen P: Nnn efficacy of low dose intradermal vaccination against hepatitis B iıı Down's syndrome Ccand J Infect Dis 25 : 16-23, 1993.
2. Bilgiç A : Hepatit B'den özgül korunma Viral Hepatit (Ed. Kılıçturgay K) Viral Hepatitle Savaşım Derneği Yayını s. 87-104, 1992.
3. Choudhury RP Cleator SJ : An examinatıon of needlestick injury rates, hepa-titis B vaccination uptake and instruction on sharp technique among medical students J Hosp Infect 22 : 143-148, 1992.
4. Hail CB Halsey NA : Control of hepatitis B. Pediatrics 29 : 274-277, 1992.
5. Mahoney FJ Woodruff BA Erben JJ Coleman PJ Reid EC Schatz GC Kane MA ; Effect of a hepatitis B vaccination program on the prevalence of hepatitis B viruş infection J Infect Dis 167 : 203-207, 1993.
6. Margolis HS : Prevention of acute and chronic liver disease through immuniza-tion J Infect Dis 168 : 9-14, 1993.
7. Milne A Waldon J : Recombinant DNA hepatitis B vaccination in teenagers J Infect Dis 166 : 942, 1992.
8. Schaffner W Gardner P Gross PA : Hepatitis B immunization strategies Ann Intern Med 118 (4) : 308-309, 1993.
9. Stevens CE Toy PT Taylor PE Lee T Yip HY : Prospects for control of hepatitis B virüs infection Pediatrics 90 : 170-173, 1992.
10. Stites DP Rodgers RPC : Clinical Laboratory Methods for Detection of Antigens and Antibodies In Basic and Clinical Immunology (Ed. Stites DP, Terr Al) 7th Ed. Prentice-Hall International Inc. pp. 217-262, 1991.