STAPHYLOCOCCUS AUREUS'UN KATI LİPİD NANOPARTİKÜLLER İLE ETKİLEŞİMİ

Amaç: Bakterilerin mevcut antibiyotiklere direnç geliştirme yeteneği, yeni antimikrobiyallerin ya da antimikrobiyal formülasyonların araştırılmasının aciliyetini ortaya koymaktadır. İlaç taşıyıcı sistemler arasında, katı lipid nanopartiküller, hedeflenen ilaç uygulaması için avantajlara sahip, çözüm odaklı sistemler olarak kabul edilir.

Anahtar Kelimeler:

Akış sitometresi, bakteriyel alım, katı lipid nanopartikül, Staphylococcus aureus

INTERACTION OF STAPHYLOCOCCUS AUREUS WITH SOLID LIPID NANOPARTICLES

Objective: The ability of bacteria to develop resistance to existing antibiotics has made the search for new antimicrobials or antimicrobial formulations a matter of urgency. Among drug delivery systems, solid lipid nanoparticles are considered solution-oriented systems with advantages for targeted drug delivery.

Keywords:

Bacterial uptake, flow cytometry, Staphylococcus aureus, solid lipid nanoparticle,

PDF

___

[1] Arana, L., Gallego, L., Alkorta, I. (2021). Incorporation of antibiotics into solid lipid nanoparticles: a promising approach to reduce antibiotic resistance emergence. Nanomaterials (Basel), 11(5), 1251. [CrossRef]
[2] WHO. (2020). Antibiotic resistance. https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance Accessed: 25.01.2022.
[3] Sofowora, A., Ogunbodede, E., Onayade, A. (2013). The role and place of medicinal plants in the strategies for disease prevention. African Journal of Traditional, Complementary and Alternative Medicines, 10(5), 210-229. [CrossRef]
[4] Yeh, Y.C., Huang, T.H., Yang, S.C., Chen, C.C., Fang, J.Y. (2020). Nano-based drug delivery or targeting to eradicate bacteria for ınfection mitigation: a review of recent advances. Frontiers in Chemistry, 8(286), 1-22. [CrossRef]
[5] Jiang, Q., Chen, J., Yang, C., Yin, Y., Yao, K. (2019). Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases. BioMed Research International, 2019, 2015978. [CrossRef]
[6] Lin, D.M., Koskella, B., Lin, H.C. (2017). Phage therapy: An alternative to antibiotics in the age of multi-drug resistance. World Journal of Gastrointestinal Pharmacology and Therapeutics, 8(3),162-173. [CrossRef]
[7] Gebreyohannes, G., Nyerere, A., Bii, C., Sbhatu, D.B. (2019). Challenges of intervention, treatment, and antibiotic resistance of biofilm-forming microorganisms. Heliyon, 5(8), e02192. [CrossRef]
[8] Marslin, G., Revina, A.M., Khandelwal, V.K., Balakumar, K., Sheeba, C.J., Franklin, G. (2015). PEGylated ofloxacin nanoparticles render strong antibacterial activity against many clinically important human pathogens. Colloids and Surfaces B: Biointerfaces, 132, 62-70. [CrossRef]
[9] Sheeba, C.J., Marslin, G., Revina, A.M., Franklin, G. (2014). Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery. Nanotechnology Reviews, 3(2), 123-151. [CrossRef]
[10] Mukherjee, S., Ray, S., Thakur, R.S. (2009). Solid lipid nanoparticles: a modern formulation approach in drug delivery system. Indian Journal of Pharmaceutical Sciences, 71(4), 349-358. [CrossRef]
[11] Munita, J.M., Arias, C.A. (2016). Mechanisms of Antibiotic Resistance. Microbiology Spectrum, 4(2). [CrossRef]
[12] Sharma, A., Vaghasiya, K., Ray, E., Verma, R.K. (2018). Nano-encapsulated HHC10 host defense peptide (HDP) reduces the growth of Escherichia coli via multimodal mechanisms. Artificial Cells, Nanomedicine, and Biotechnology, 46(3), 156-165. [CrossRef]
[13] Tong, S.Y., Davis, J.S., Eichenberger, E., Holland, T.L., Fowler, V.G. (2015). Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clinical Microbiology Reviews, 28(3): 603-661. [CrossRef]
[14] Oogai, Y., Matsuo, M., Hashimoto, M., Kato, F., Sugai, M., Komatsuzawa, H. (2011). Expression of virulence factors by Staphylococcus aureus grown in serum. Applied and Environmental Microbiology, 77(22), 8097-8105. [CrossRef]
[15] Chambers, H.F., Deleo, F.R. (2009). Waves of resistance: Staphylococcus aureus in the antibiotic era. Nature Reviews Microbiology, 7(9), 629-641 [CrossRef]
[16] Shapiro, H.M. (2001). Optical measurements in cytometry: light scattering, extinction, absorption, and fluorescence. Methods in Cell Biology, 63, 107-129. [CrossRef]
[17] Zucker, R.M., Daniel, K.M. (2012). Detection of TiO2 nanoparticles in cells by flow cytometry. Methods in Molecular Biology, 906, 497-509. [CrossRef]