Meliha GÜNEŞ, Gökçe TURAN, Armağan DÖNMEZER, Fadime AYDIN KÖSE, Kevser Özgen ÖZER, Sinem Yaprak KARAVANA

PARKİNSON TEDAVİSİ İÇİN RASAJİLİN MESİLAT MUKOADEZİF AĞIZDA DAĞILAN FİLM FORMÜLASYONLARI

Amaç: Bu makale, Parkinson Hastalığının oral olmayan tedavisi için Rasagilin mesilat (RM) ağızda dağılan filmlerin (ODF'ler) formülasyon çalışmalarını ve in vitro değerlendirmesini içermektedir. RM, özellikle yoğun hepatik biyotransformasyona uğrayan geri döndürülemez ve yüksek seçiciliğe sahip bir MAO-B inhibitörüdür. Karaciğerde metabolize edilir ve oral biyoyararlanımı yaklaşık %36 ve yarılanma ömrü 3 saattir. Bu özellikler, RM'nin bukkal ilaç dağıtımı için mükemmel bir aday olabileceğini göstermektedir.

Anahtar Kelimeler:

Ağızda dağılan film, bukkal uygulama, polietilen oksit, rasajilin mesilat

MUCOADHESIVE ORODISPERSIBLE FILM FORMULATIONS OF RASAGILINE MESYLATE FOR PARKINSON TREATMENT

Objective: The article is included formulation studies and in vitro evaluation of orally dispersible Rasagiline mesylate (RM) orodispersible films (ODFs) for non-oral treatment of Parkinson's Disease. RM undergoes extensive hepatic biotransformation and is a highly selective and irreversible MAO-B inhibitor. It is metabolized in the liver and has an oral bioavailability of approximately 36% and a half-life of 3 hours. These properties suggest that RM may be an excellent candidate for buccal drug delivery.

Keywords:

Buccal delivery, orodispersible film, polyethylene oxide, rasagiline mesylate,

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