ENTEGRE BİYOİNFORMATİK ANALİZ İLE KRONİK LENFOSİTİK LÖSEMİDE HEDEF GENLERİN VE YOLAKLARIN BELİRLENMESİ

Amaç: En yaygın lösemi türü olan kronik lenfositik lösemi (KLL), kanda, kemik iliğinde ve lenfoid organda spesifik bir immünofenotipe sahip monoklonal B hücrelerinin ilerleyici birikimi ile karakterize edilir. Bu çalışmanın amacı, biyoinformatik analiz yaparak KLL’nin altında yatan moleküler mekanizmaları araştırmak, KLL tanı ve tedavisi için potansiyel hedefleri belirlemektir.

INTEGRATED BIOINFORMATIC ANALYSIS TO EVALUATE TARGET GENES AND PATHWAYS IN CHRONIC LYMPHOCYTIC LEUKEMIA

Objective: The most common type of leukemia, chronic lymphocytic leukemia (CLL), is characterized by progressive accumulation of monoclonal B cells with a specific immunophenotype in the blood, bone marrow, and lymphoid organ. The goal of this research was to use bioinformatic analysis to comprehend the molecular mechanisms causing CLL and to investigate potential targets for the diagnosis and therapy of CLL.

Keywords:

Bioinformatic analysis, CLL, GEO, microarray network module,

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