BAZI MICHAEL TİPİ KATIM ÜRÜNLERİNİN SENTEZ ÇALIŞMASI VE ANTİMİKROBİYAL AKTİVİTELERİ
Amaç: Çoklu ilaca dirençli patojenik bakteri, mantar ve Mycobacterium tuberculosis enfeksiyonları dünya çapında giderek yaygınlaşmaya devam etmektedir. Organik kimyada, tiya-Michael tipi katım ayrıca biyoaktif bileşiklerin sentezinde önemli bir reaksiyondur. Bu çalışmada, 2-amino-3-[(2-nitro-1-fenilpropil)tiyo]propanoik asit Michael tip yeni katım ürünlerinin (IIa-IIg) sentezi ve antibakteriyel, antifungal ve antitüberküler aktivitelerinin araştırılması amaçlanmıştır.
STUDY ON SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME MICHAEL-TYPE ADDITION COMPOUNDS
Objective: Multidrug-resistant pathogenic bacteria, fungi, and Mycobacterium tuberculosis infections continue to be increasingly widespread worldwide. In organic chemistry, the tiya-Michael type addition is also significant reaction in the synthesis of bioactive compounds. In this study, the aim is to synthesize the series of new Michael type addition products 2-amino-3-[(2-nitro-1-phenylpropyl)thio]propanoic acid (IIa-IIg) and to investigate their in vitro, antibacterial, antifungal and antitubercular activity.
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