Türk Behçet hastalarının cinsiyet, HLA-B51 ve paterji testine göre klinik özelliklerinin değerlendirilmesi

Purpose: The clinical features of Behçet disease (BD) are variable between race and country. Gender, pathergy test and HLA B51 also have impact on clinical manifestations of BD. The aim of this study is to investigate clinical evaulation of Turkish patients with BD according to gender, HLA B51 and pathergy test. Material and Method: 97 Turkish patients (59 males, 38 females) fulfilling the International Study Group criteria for Behçet Disease were evaulated retrospectively. Results The mean age was 36,2 ± 11,1 years. The median (IQR: interquartile range) age at diagnosis, duration of disease and delay in diagnosis were 26 (14), 7 (8) and 4 (8) years. Oral aphtous ulcers were the most common manifestation (100%), followed by genital ulcers (%67), skin findings (54,6%), ocular (51,5%) and vascular involvement (24,7%), arthritis (23,7%) and neurologic involvement (14,4%). HLA B51 and Pathergy test were positive in 70,1% and 39,2% of patients, respectively. Genital ulcer, skin findings and articular involvement and HLAB51 positivity were similiar between male and female gender. Pathergy positivity, ocular and vascular involvement were more common in men. Skin findings more rare in pathergy positive group. Conclusion : The clinical manifestations of BD in Turkish patients were influenced by gender, rahter than pathergy and HLA B51 positivity. Key words: Behçet Disease, HLA B51, pathergy test, gender Amaç: Behçet hastalığının (BH) klinik özellikleri ülkeye ve ırk’a göre farklılık gösterebilmektedir. Cinsiyet, paterji testi ve HLA B51 de BH’nın klinik özelliklerini etkileyebilmektedir. Bu çalışmanın amacı; cinsiyet, HLA B51 ve paterji testinin Türk Behçet hastalarının kliniğine etkisini değerlendirmektir. Gereç ve Yöntem: International Study Group kriterlerine göre BH tanısı almış 97 Türk hasta retrospektif olarak değerlendirildi. Bulgular: Ortalama yaş 36.2 ± 11.1 yıl idi. Medyan (ÇAA:çeyreklerarası aralık) tanı yaşı, hastalık süresi ve tanıda gecikme yaşı; 26 (14), 7 (8) and 4 (8) yıl idi. Oral aftöz ülserler en sık gözlenen bulguydu(%100). Oral ülserleri, genital ülserler (%67), cilt bulguları (%54,6), oküler (%51,5) ve vasküler tutulum (%24,7), artrit (%23,7) ve nörolojik tutulum (%14,4) izlemekteydi. HLA B51 ve paterji testi, hastaların % 70,1’inde ve %39,2’sinde pozitifti. Genital ülser, cilt bulguları, artiküler tutulum ve HLA B51 pozitifliği erkek ve kadın cinsiyette benzerdi. Paterji pozitifliği, oküler ve vasküler tutulum erkeklerde daha fazlaydı. Paterji pozitif olan grupta cilt bulguları daha nadirdi. Sonuç: Türk Behçet hastalarının klinik özellikleri cinsiyetten belirgin olarak etkilenirken, paterji ve HLA B51 pozitifliğinden pek etkilenmemektedir. Anahtar kelimeler: Behçet hastalığı, HLA B51, paterji testi, cinsiyet

Anahtar Kelimeler:

Behçet hastalığı, HLA B51, paterji testi, cinsiyet

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