Eylem Karatay, Sezai Kalkan, Erdem Akbal

ERKEN DÖNEM TİP 2 DİYABETES MELLİTUS HASTALARINDA POSTPRANDİYAL RAHATSIZLIK SENDROMU‘NUN YAŞAM KALİTESİ ÜZERİNE ETKİLERİNİN DEĞERLENDİRİLMESİ

Amaç: Erken dönem komplikasyon gelişmemiş Tip 2 DiyabetesMellitus hastalarında ve sağlıklı kontrol grubunda yaşam kalitesiskorlarını karşılaştırmak ve postprandiyal rahatsızlık sendromununyaşam kalitesi üzerine etkilerinin değerlendirilmesi amaçlandı.Gereç ve yöntem: Bu vaka kontrol çalışmasına erken dönemkomplikasyon gelişmemiş olan 59 tip 2 diyabetes mellitus hastası veherhangi bir sistemik hastalığı ve ilaç kullanımı olmayan benzer yaş vecinsiyette olan 92 hasta dahil edildi. Hastaların cinsiyet, yaş, boy, kilo,sigara, alkol kullanımları, postprandiyal rahatsızlık sendromu varlığısorgulandı. Hastaların yaşam kaliteleri Kısa Form Sağlık (SF-12) ölçeğitesti aracılığıyla sorgulandı. SF-12 skorları iki alt bileşen olan fizikselişlevselliği gösteren Fiziksel Bileşen Özeti Skoru (PCS) ve zihinsel alanıgösteren Zihinsel Bileşen Özeti Skoru (MCS) ile değerlendirildi.Bulgular: Hasta grubu ile kontrol grubu cinsiyet (p=0,430),yaş (p=0,857), sigara (p=0,807) ve alkol kullanımı (p=0,745)açısından benzerdi. Hasta grubunun vücut kitle indeksi ortalamalarıkontrol grubuna göre daha yüksekti (p=0,001) ve hasta grubundapostprandiyal rahatsızlık sendromu sıklığı (p=0,001) daha fazlaydı.Hasta grubunun hesaplanan PCS puan ortalamaları tek değişkenlianalizlerde kontrol grubuna göre daha düşükken (p=0,006), çokdeğişkenli analizlerde hasta grubu ile kontrol grubu arasında farkyoktu. MCS skorlarının çok değişkenli analizlerde vücut kitle indeksiyüksek olanlarda ve postprandiyal rahatsızlık sendromu olanlardadaha düşük olduğu görüldü.Sonuç: Çalışmamızda erken dönem komplikasyon gelişmemişTip 2 diyabetes mellitus hastalarında yaşam kalitesinin diyabetleilişkili olarak düşmediği tespit edilmiştir. Postprandiyal rahatsızlıksendromunun ve yüksek vücut kitle indeksinin yaşam kalitesiüzerine olumsuz etkileri olduğu gözlemlenmiştir.

EVALUATION OF THE EFFECTS POST POSTPRANDIAL DISCOMFORT SYNDROME ON QUALITY OF LIFE IN EARLY TYPE 2 DIABETES MELLITUS PATIENTS

PURPOSE: The aim of this study was to compare the quality of life scores of patients with type 2 diabetes mellitus who had no complications, and healthy controls and to evaluate the effects of postprandial distress syndrome on quality of life. Material and methods This case control study included 59 patients with type 2 diabetes mellitus, and age and sex-matched 92 healthy individuals without any systemic disease or drug use. Gender, age, height, weight, smoking, alcohol use and presence of postprandial distress syndrome were questioned. Quality of life of the patients was evaluated through the Short Form Health Scale Test (SF-12). SF-12 scores were assessed on two sub-components: Physical Component Score (PCS) showing physical functionality and Mental Component Score (MCS) showing mental area. Results: The patient group and control group were similar in terms of gender (p=0.430), age (p=0.857), smoking (p=0.807), and alcohol use (p=0.745). The mean body mass index (BMI) of the patient group was higher than the control group (p=0.001) and the incidence of postprandial distress syndrome (p=0.001) was higher in the patient group. While the mean PCS score of the patient group was lower in univariate analysis than in the control group (p=0.006), there was no difference between the patient group and the control group in multivariate analyzes. In multivariate analyzes, MCS scores were found to be lower in patients with high BMI and postprandial distress syndrome. Conclusion: In our study, quality of life was not decreased with presence of early period diabetes. The presence of postprandial distress syndrome and higher BMI had negative effects on quality of life.

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1.)Cho N, Shaw J, Karuranga S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes research and clinical practice. 2018;138:271-281.
2.)Conti C, Mennitto C, DiFrancesco G, Fraticelli F, Vitacolonna E, Fulcheri M. Clinical characteristics of diabetes mellitus and suicide risk. Frontiers in psychiatry. 2017;8:40.
3.)Satman I, Omer B, Tutuncu Y, et al. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol. 2013;28(2):169-180.
4.)Cervino G, Terranova A, Briguglio F, et al. Diabetes: Oral health related quality of life and oral alterations. BioMed research international. 2019;2019:5907195.
5.)Li H, Ji M, Scott P, Dunbar-Jacob JM. The Effect of Symptom Clusters on Quality of Life Among Patients With Type 2 Diabetes. The Diabetes Educator. 2019;45(3):287-294.
6.)López-Bastida J, López-Siguero JP, Oliva-Moreno J, et al. Healthrelated quality of life in type 1 diabetes mellitus pediatric patients and their caregivers in Spain: an observational cross-sectional study. Current medical research and opinion. 2019;9:1-7.
7.)Pan C-W, Wang S, Wang P, Xu C-L, Song E. Diabetic retinopathy and health-related quality of life among Chinese with known type 2 diabetes mellitus. Quality of Life Research. 2018;27(8):2087-2093.
8.)Sothornwit J, Srisawasdi G, Suwannakin A, Sriwijitkamol A. Decreased health-related quality of life in patients with diabetic foot problems. Diabetes, metabolic syndrome and obesity: targets and therapy. 2018;11:35-43.
9.)Gangula AR, Reddy G, Divyaja M, Reddy KSK. Effect of Patient Counseling in Improving Physical and Mental Health of Type-2 Diabetes Mellitus Patients. Research & Reviews: Journal of Medicine. 2019;4(2):16-19.
10.)Puvvada RC, Muthukumar VA. Impact of patient counselling on the knowledge, attitude, practice and quality of life in patients with hypertension with diabetes mellitus-II.Indian journal of Pharmaceutical Education and Research. 2018;52(2):305-310.
11.)Arditi C, Zanchi A, Peytremann-Bridevaux I. Health status and quality of life in patients with diabetes in Switzerland. Primary care diabetes. 2019;13(3):233-241.
12.)Xia HH, Talley NJ, Kam EP, Young LJ, Hammer J, Horowitz M. Helicobacter pylori infection is not associated with diabetes mellitus, nor with upper gastrointestinal symptoms in diabetes mellitus. Am J Gastroenterol. 2001;96(4):1039-1046.
13.)Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006;130(5):1377-1390.
14.)Chassany O, Marquis P, Scherrer B et al.Validation of a spesific quality of life questionnaire for functional digestive disorders. Gut 1999; 44(4):527-533.15
15.)Diabetes Control and Complications Trial Research Group. Lifetime benefits and coast of intensive therapy as practiced in the diabetes control and complications trial. JAMA 1996;276:1409-1415
16.)Organization WH. Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO/IDF consultation. 2006.
17.)Ware Jr JE, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Medical care. 1996;34(3): 220-233.
18.)Ware JE, Kosinski M. SF-36 physical & mental health summary scales: a manual for users of version 1. Quality Metric; 2001.
19.)Wexler D, Grant R, Wittenberg E, et al. Correlates of health-related quality of life in type 2 diabetes. Diabetologia. 2006;49(7):1489-1497.
20.)Goel M, Dhuldhule S, Prakash A, Ghotekar LH. Assessing health-related quality of life in patients with diabetes mellitus at a Tertiary Care Center in Central Delhi. Indian Journal of Community Medicine. 2019;44(2):171.
21.)Kazemi-Galougahi M, Ghaziani HN, Ardebili HE, Mahmoudi M. Quality of life in type 2 diabetic patients and related effective factors. Indian journal of medical sciences. 2012;66: 230-7.
22.)Garcia JM, Cox D, Rice DJ. Association of physiological and psychological health outcomes with physical activity and sedentary behavior in adults with type 2 diabetes. BMJ Open Diabetes Research and Care. 2017;5(1):e000306.
23.)Schram MT, Baan CA, Pouwer F. Depression and quality of life in patients with diabetes: a systematic review from the European depression in diabetes (EDID) research consortium. Current diabetes reviews. 2009;5(2):112-119.
24.)Tang YH, Pang SM, Chan MF, Yeung GS, Yeung VT. Health literacy, complication awareness, and diabetic control in patients with type 2 diabetes mellitus. Journal of advanced nursing. 2008;62(1):74-83.
25.)Jannoo Z, Wah YB, Lazim AM, Hassali MA. Examining diabetes distress, medication adherence, diabetes self-care activities, diabetesspecific quality of life and health-related quality of life among type 2 diabetes mellitus patients. Journal of clinical & translational endocrinology. 2017;9:48-54.
26.)Wong EM, Afshar R, Qian H, Zhang M, Elliott TG, Tang TS. Diabetes distress, depression and glycemic control in a Canadianbased specialty care setting. Canadian journal of diabetes. 2017;41(4):362-365.
27.)Williamson DA, Rejeski J, Lang W, Van Dorsten B, Fabricatore AN, Toledo K. Impact of a weight management program on healthrelated quality of life in overweight adults with type 2 diabetes. Archives of internal medicine. 2009;169(2):163-171.
28.)Fontaine KR, Cheskin LJ, Barofsky I. Health-related quality of life in obese persons seeking treatment. Journal of Family Practice. 1996;43(3):265-271.
29.)Stewart AL, Greenfield S, Hays RD, et al. Functional status and well-being of patients with chronic conditions: results from the Medical Outcomes Study. Jama. 1989;262(7):907-913.
30.)Lee AA, Hasler WL. Diabetes and the Stomach. Curr Treat Options Gastroenterol. 2017;15(4):441-459.