Koray ERGÜNAY, Zeliha KOÇAK TUFAN, Tümer GÜVEN, Gül Ruhsar YILMAZ, Mehmet Akın TAŞYARAN, Rahmet GÜNER, Fatma ESER

BİR BATI NİL ATEŞİ OLGUSU

Batı Nil virusu (BNV), Culex cinsi sivrisinekler ile bulaşan Flaviviridae ailesinde sınıflandırılan bir virustur. Virusa maruziyet %80 asemptomatik infeksiyon ile sonuçlanırken, olguların %20 sinde Batı Nil ateşi adı verilen ateş ile seyreden bir klinik tablo, %1'den az oranda santral sinir sistemi bulguları ve nöroinvazif hastalık gelişmektedir. Hastanemize Eylül 2012'de ateş yüksekliği, yaygın myalji ile başvuran hastada Batı Nil ateşi hastalığı düşünülmüş ve tanı kan örneğinde Batı Nil virüsü nested PCR'ın pozitif, sekans analizinin de uyumlu olması ile doğrulanmıştır.

A WEST NİLE FEVER CASE

West Nile virus (WNV) is a virus belongs to Flaviviridae family and transmitted by Culex species of mosquito. Infection with virus result in %80 of infected individuals are asymptomatic, %20 of individuals are have clinical presentation with fever as termed West Nile fever, less than %1 of individuals have central nervous system finding and neuroinvasive disease. The patient applied to our hospital in September 2012 with fever and widespread myalgia, preliminary diagnosis thought as West Nile fever and confirmed with nested PCR positivity and sequence analysis compatibility.

PDF

___

1)Epidemic/Epizootic West Nile Virus in the United States: Guidelines for Surveillance, Prevention and Control. Accessed: 10 March 2011.
2)Chowers M. West Nile fever. In: Schwartz E (ed). Tropical Diseases in Travelers. 1st ed. Singapore: Blackwell Publishing. 2009: 65-73.
3)Green S, Rothman AL. West Nile virus. In: Gorbach SL, Bartlett JG, Blacklow NR (eds). Infectious Diseases. 3rd ed. Philadelphia: Lippincott Williams and Wilkins. 2004: 2128-32.
4)Hayes EB, Gubler DJ. West Nile virus: epidemiology and clinical features of an emerging epidemic in the United States. Annu Rev Med. 2006; 57: 181-94.
5)West Nile virus circulation in the EpiSouth countries and neighbouring areas (Hungary and Russia) Update 6th of October 2010. Accessed: 22 March 2011.
6)Kalaycioglu H, Korukluoglu G, Ozkul A, et al. Emergence of West Nile virus infections in humans in Turkey, 2010 to 2011. Eur Surveill. 2012; 17: pii 20182.
7)Turkish Statistical Institute (TUIK). 2009 Address Based Population Registration System. [Accessed 15 Jan 2011].
Available from: http://www.tuik.gov.tr/PreHaberBultenleri.do?id=8428&tb_id=3 8)Ocal M, Onder H, Arsava EM, Alp S, Ozkul A, Ergünay K. A case of central nervous system infection due to west nile virus lineage-1 in Ankara province, Turkey Mikrobiyol Bul. 2013; 47: 164-72.
9)Yeşilkaya A, Kurt Azap O, Arslan H, et al. A fatal case of West Nile virus encephalitis. Mikrobiyol Bul. 2012; 46: 488-92.
10)West Nile Fever. European Centre for Disease Prevention and Control. Accessed: 10 March 2011.
11)Weiss D, Carr D, Kellachan J, et al. Clinical findings of West Nile virus infection in hospitalized patients, New York and New Jersey, 2000. Emerg Infect Dis. 2001; 7: 654-8.
12)Chowers MY, Lang R, Nassar F, et al. Clinical characteristics of the West Nile fever outbreak, Israel, 2000. Emerg Infect Dis. 2001; 7: 675-8.
13)Brilla R, Block M, Geremia G, Wichter M. Clinical and neuroradiologic features of 39 cases of West Nile virus meningoencephalitis. J Neurol Sci. 2004; 220: 37-40.
14)Koçak Tufan Z, Bulut C. West Nile Virus Infections, Flora. 2011; 16: 1-9.
15)Alp-Çavuş S ve ark. Batı Nil Ateşi: Türkiye'de bildirilen ilk salgının devamında kliniğimize başvuran dört olgu., Rukiye 15.Türk Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Kongre Kitabı. 2011; S181.