Habip ATALAY, Levent KAPLAN, Canan BALCI, Bahadır SAVAŞ, Mustafa GÖNÜLLÜ

Rokuronyum ile propofol-$N_{2}O$ ve tiyopental-sevofluran-$N_{2}O$ anestezilerinin etkileşimi

Rokuronyumun farmakokinetik özellikleri, 15'er olguluk iki grupta tiyopental-sevofluran-N2O ve propofol-N2O anestezikleriyle etkileşimi incelenmiş ve indüksiyondaki hemodinamik değişiklikler değerlendirilmiştir. Rokuronyumun maksimal etki başlama zamanı; tiyopental-sevofluran-N2O anestezisi ile 157±28 sn, propofol-N2O anestezisi ile 134±42 sn ve etki süresi her iki grupta yaklaşık 40 dakika olarak belirlendi. Derlenme süresi tiyopental-sevofluran-N2O'de propofol-N2O'e göre belirgin olarak uzamaktadır (58±15 dk'ya karşı 44±10 dk). İndüksiyonda kalp atım hızı propofol-N2O ile minimal azalma eğiliminde olmuştur. Tiyopental-sevofluran-N2O rokuronyumun etkisini propofol-N2O'den daha fazla potansiyalize ettiği sonucuna varıldı.

Anahtar Kelimeler:

Anestezi, Farmakokinetik, Tiyopental, Propofol

Interaction of rocuronium with propofol-$N_{2}O$ or thiopentone-sevoflurane-$N_{2}O$ anesthesia

Pharmacokinetic properties of rocuronium are evaluted in two groups each consisting of 15 patients scheduled to undergo thiopentone-sevoflurane-N2O or propofol-N2O anesthesia. Hemodynamic alterations during the induction period were examined. Maximal effect of rocuronium is 134±42 sec with thiopentone-sevoflurane-N2O, and it is 134±42 sec with propofol-N2O anesthesia. Duration of action is nearly 40 min in both groups. Spontaneous recovery time is significantly longer with sevoflurane-N2O than propofol-N2O anesthesia (58±15 min 44±10 min). Heart rate declined slightly with propofol-N2O. It is concluded that sevoflurane-N2O anesthesia potentiated the effect of rocuronium much more than propofol-N2O

Keywords:

Anesthesia, Pharmacokinetics, Thiopental, Propofol,

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