ATEŞ DUMAN, Alper YOSUNKAYA, Öztin Cemile ÖĞÜN, Adnan ABASIYANIK, Zafer DAŞCI

Karbondioksit ve azotprotoksit pnömoperitonyumunun hemodinamik ve kan gazı etkilerinin yavru köpek modelinde araştırılması

Laparoskopi amacıyla oluşturulan pnömoperitonyum için kullanılan karbondioksit (CO2) ve azot protoksitin (N2O) çocuklarda hemodinamiye ve kan gazlarına etkileri yavru köpek modeli kullanılarak araştırıldı. Köpekler (n=22) xylazin ile premedike edilip, ketamin 30 mg.kg-1 (im) ile anestetiğe edildikten sonra, femoral arter ve safen venine kanüller yerleştirildi. Grup I'e (n=II) intraperitoneal olarak 10-12 mmHg basınçla CO2, grup H'ye (n=II) N2O verildi. Kalp atım hızları (KAH), sistolik (SAB), diyastolik (DAB) ve ortalama (OAB) arter basınçları, kan gazlan (PaO2, PaCO2), solunum havasındaki end tidal karbon dioksit (ETCO2) ve %N2O değerleri işlem öncesi (kontrol) insuflasyon sonrası (İS) 15. dakika ve desuflasyon sonrası (DS) 15. dakikalarda kaydedildi. İstatistiksel değerlendirmede tekrarlayan ölçümlerde varyans analizi kullanıldı, p

Anahtar Kelimeler:

Ksilazin, Kan gazı analizi, Nitröz oksit, Pnömoperitonyum, Karbon dioksit, Hiperkapni, Laringoskopi, Köpekler, Varyans analizi, Premedikasyon

The hemodynamic and blood gas effects of carbondioxide and nitrous oxide pneumoperitoneum in dogs

The effects of carbon dioxide (CO2) and nitrous oxide (N2O) pneumoperitoneum on hemodynamics and blood gases in children were studied using a puppy model. After premedication with xylazine, 22 dogs were anesthetized with 30 mg.kg--1 i.m. ketamine and femoral artery andsaphenous veins were canulated. Insufflation was conducted with a pressure of 10-12 mmHg of CO2 in group I (n=II) and N2O in group II (n=II). Heart rate (HR), sysiolics (SAP) diastolic (DAP) and mean (MAP) arterial pressures, blood gases (PaO2, PaCO2); end tidal carbon dioxide (ETCO2) and N2O % during expirium were recorded before insufflation (control), 15 minutes after insufflation (AI) and 15 minutes after desufflation (AD). Variance analysis for repeated measures were used for statistics, p<0.05 was considered as significant. HR, SAP, DAP, MAP, ETCO2 and PaCO2 increased AI in Group I. SAP decreased AI and DAP increased AD in Group II. MAP AI was higher in Group I,. PaCO2 and ETCO2 were higher in Group I, AI and AD. In Group II, N2O was not recorded in expired air. It is concluded that N2O may be an alternative to CO2 for children that are at risk for hypercarbia.

Keywords:

Xylazine, Blood Gas Analysis, Nitrous Oxide, Pneumoperitoneum, Carbon Dioxide, Hypercapnia, Laryngoscopy, Dogs, Analysis of Variance, Premedication,

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