Ahmet Emre YILDIZ, Hakan Görkem KAZICI, Erhan ATEŞ

COVID-19 pandemisinin erkek cinsel sağlığı ve semen parametreleri üzerine etkileri

COVID-19 pandemisi vücudumuzda birçok organ ve sistemi etkilediği gibi genitoüriner sistem ve cinsel sağlık üzerinde de olumsuz etkilere neden olmuştur. Bu derlemede COVID-19 pandemisinin erkek cinsel sağlığı üzerindeki etkileri değerlendirilmiştir. Literatürdeki verilere göre COVID-19 pandemisi sürecinde erkeklerde erektil disfonksiyonda artma, ejakülasyon süresinde kısalma, semen parametrelerinde bozulma olduğu ve cinsel alışkanlıkların pandemi sürecinden etkilendiği saptanmıştır.

Effects of the COVID-19 pandemic on male sexual health and semen parameters

The COVID-19 pandemic has had negative effects on the genitourinary system and sexual health, as well as affecting many organs and systems in our body. In this review, the effects of the COVID-19 pandemic on male sexual health were evaluated. According to the data in the literature, it has been determined that during the COVID-19 pandemic, men have increased erectile dysfunction, shortened ejaculation time, impaired semen parameters, and sexual habits have been affected by the pandemic process.

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1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (London, England). 2020;395(10223):497–506. [CrossRef ]
2. Soytaş M, Boz MY, Güzelburç V, Çalik G, Horuz R, Akbulut Z, Albayrak S. Comparison of before and after COVID-19 urology practices of a pandemic hospital. Turkish J Urol. 2020;46(6):474– 80. [CrossRef ]
3. Madanelo M, Ferreira C, Nunes-Carneiro D, Pinto A, Rocha MA, Correia J, et al. The impact of the coronavirus disease 2019 pandemic on the utilisation of emergency urological services. BJU Int. 2020;126(2):256–8. [CrossRef ]
4. Li W, Li J, Yi J. Government management capacities and the containment of COVID-19: a repeated cross-sectional study across Chinese cities. BMJ Open. 2021;11(4):e041516. [CrossRef ] 5. Teixeira TA, Oliveira YC, Bernardes FS, Kallas EG, Duarte- Neto AN, Esteves SC, et al. Viral infections and implications for male reproductive health. Asian J Androl. 2021;23(4):335–47. [CrossRef ]
6. Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, Rubin GJ. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet [Internet]. 2020;395(10227):912–20. [CrossRef ]
7. Yiou R. Stem-cell therapy for erectile dysfunction. Biomed Mater Eng. 2017;28(s1): S81–5. [CrossRef ]
8. Gratzke C, Angulo J, Chitaley K, Dai Y-T, Kim NN, Paick J-S, et al. Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med. 2010;7(1 Pt 2):445–75. [CrossRef ]
9. Kresch E, Achua J, Saltzman R, Khodamoradi K, Arora H, Ibrahim E, et al. COVID-19 Endothelial Dysfunction Can Cause Erectile Dysfunction: Histopathological, Immunohistochemical, and Ultrastructural Study of the Human Penis. World J Mens Health. 2021;39(3):466–9. [CrossRef ]
10. Hsieh T-C, Edwards NC, Bhattacharyya SK, Nitschelm KD, Burnett AL. The Epidemic of COVID-19-Related Erectile Dysfunction: A Scoping Review and Health Care Perspective. Sex Med Rev. 2021;10(2):286–310. [CrossRef ]
11. Sansone A, Mollaioli D, Ciocca G, Colonnello E, Limoncin E, Balercia G, Jannini EA. “Mask up to keep it up”: Preliminary evidence of the association between erectile dysfunction and COVID-19. Andrology. 2021;9(4):1053–9. [CrossRef ]
12. Rao TSS, Andrade C. Sexual Behavior in the Days of COVID-19. J Psychosexual Health [Internet]. 2020;2(2):111–2. [CrossRef ]
13. Sansone A, Mollaioli D, Ciocca G, Limoncin E, Colonnello E, Vena W, Jannini EA. Addressing male sexual and reproductive health in the wake of COVID-19 outbreak. J Endocrinol Invest. 2021;44(2):223–31. [CrossRef ]
14. Karkin K, Alma E. Erectile dysfunction and testosterone levels prior to COVID-19 disease: What is the relationship? Arch Ital Urol Androl. 2021;93(4):460–4. [CrossRef ]
15. Thomas C, Konstantinidis C. Neurogenic Erectile Dysfunction. Where Do We Stand? Med (Basel). 2021;8(1):3. [CrossRef ]
16. Beghi E, Feigin V, Caso V, Santalucia P, Logroscino G. COVID-19 Infection and Neurological Complications: Present Findings and Future Predictions. Neuroepidemiology. 2020;54(5):364–9. [CrossRef ]
17. Abbas AM, Fathy SK, Khamees AA, Salem AS, Ahmed L. A focused review on the genital and sexual affection of COVID-19 patients. J Gynecol Obstet Hum Reprod [Internet]. 2020;49(8):101848. [CrossRef ]
18. White A. Men and COVID-19: the aftermath. Postgrad Med. 2020;132(Sup 4):18–27. [CrossRef ]
19. Andersen ML, Tufik S. The Association Between Sleep Disturbances and Erectile Dysfunction During the COVID-19 Pandemic. Sex Med Rev. 2022;10(2):263–70. [CrossRef ]
20. Mollaioli D, Sansone A, Ciocca G, Limoncin E, Colonnello E, Di Lorenzo G, Jannini EA. Benefits of Sexual Activity on Psychological, Relational, and Sexual Health During the COVID-19 Breakout. J Sex Med. 2021;18(1):35–49. [CrossRef ]
21. Duran MB, Yildirim O, Kizilkan Y, Tosun C, Cirakoglu A, Gultekin MH, et al. Variations in the Number of Patients Presenting With Andrological Problems During the Coronavirus Disease 2019 Pandemic and the Possible Reasons for These Variations: A Multicenter Study. Sex Med. 2021;9(1):100292. [CrossRef ]
22. Ates E, Kazici HG, Yildiz AE, Sulaimanov S, Kol A, Erol H. Male sexual functions and behaviors in the age of COVID-19: Evaluation of mid-term effects with online cross-sectional survey study. Arch Ital Urol Androl. 2021;93(3):341–7. [CrossRef ]
23. Harirugsakul K, Wainipitapong S, Phannajit J, Paitoonpong L, Tantiwongse K. Erectile dysfunction among Thai patients with COVID-19 infection. Transl Androl Urol. 2021;10(12):4376–83. [CrossRef ]
24. Fang D, Peng J, Liao S, Tang Y, Cui W, Yuan Y, et al. An Online Questionnaire Survey on the Sexual Life and Sexual Function of Chinese Adult Men During the Coronavirus Disease 2019 Epidemic. Sex Med [Internet]. 2021;9(1):100293. [CrossRef ]
25. Pintea-Trifu M. Erectile dysfunction and premature ejaculation during the pandemic caused by the sars-cov-2 virus. Int J Adv Stud Sexol. 2021;3(1):33–9. [CrossRef ]
26. Hafi B, Uvais NA. Loss of Erection Followed by Spontaneous Ejaculation: A COVID-19 Phenomenon? Prim Care Companion CNS Disord. 2021;23(6). [CrossRef ]
27. Sizar O, Schwartz J. Hypogonadism. Treasure Island (FL): StatPearls Publishing; 2022.
28. Li M-Y, Li L, Zhang Y, Wang X-S. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect Dis Poverty. 2020;9(1):45. [CrossRef ]
29. Zhang J, Wu Y, Wang R, Lu K, Tu M, Guo H, et al. Bioinformatic analysis reveals that the reproductive system is potentially at risk from SARS-CoV-2. Preprints.org [Internet]. 2020;(February):1–15. [CrossRef ]
30. Ma L, Xie W, Li D, Shi L, Ye G, Mao Y, et al. Evaluation of sexrelated hormones and semen characteristics in reproductive-aged male COVID-19 patients. J Med Virol. 2021;93(1):456–62. [CrossRef ]
31. Rastrelli G, Di Stasi V, Inglese F, Beccaria M, Garuti M, Di Costanzo D, et al. Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients. Andrology. 2021;9(1):88–98. [CrossRef ]
32. Çayan S, Uğuz M, Saylam B, Akbay E. Effect of serum total testosterone and its relationship with other laboratory parameters on the prognosis of coronavirus disease 2019(COVID-19)in SARS-CoV-2 infected male patients: a cohort study. Aging Male. 2020;23(5):1493–503. [CrossRef ]
33. Salonia A, Pontillo M, Capogrosso P, Gregori S, Tassara M, Boeri L, et al. Severely low testosterone in males with COVID-19: A case-control study. Andrology. 2021;9(4):1043–52. [CrossRef ]
34. Cristian D, Baruh I, Hunor M. Sexual life during covid-19. Int J Adv Stud Sex. 2021;3(1):20–5. [CrossRef ]
35. Lau WK-W, Ngan LH-M, Chan RC-H, Wu WK-K, Lau BW-M. Impact of COVID-19 on pornography use: Evidence from big data analyses. PLoS One. 2021;16(12):e0260386. [CrossRef ]
36. Rodríguez-Domínguez C, Lafuente-Bacedoni C, Durán M. Effect of the Lockdown Due to COVID-19 on Sexuality: The Mediating Role of Sexual Practices and Arousal in the Relationship Between Gender and Sexual Self-Esteem. Psychol Rep. 2021;332941211028999. [CrossRef ]
37. Li G, Tang D, Song B, Wang C, Qunshan S, Xu C, et al. Impact of the COVID-19 Pandemic on Partner Relationships and Sexual and Reproductive Health: Cross-Sectional, Online Survey Study. J Med Internet Res. 2020;22(8):e20961. [CrossRef ]
38. Masoudi M, Maasoumi R, Bragazzi NL. Effects of the COVID-19 pandemic on sexual functioning and activity: a systematic review and meta-analysis. BMC Public Health. 2022;22(1):189. [CrossRef ]
39. Karagöz MA, Gül A, Borg C, Erihan İB, Uslu M, Ezer M, et al. Influence of COVID-19 pandemic on sexuality: a cross-sectional study among couples in Turkey. Int J Impot Res. 2020;33(8):815– 23. [CrossRef ]
40. Chow EP, Hocking JS, Ong JJ, Phillips TR, Schmidt T, Buchanan A, et al. Brief Report: Changes in PrEP Use, Sexual Practice, and Use of Face Mask During Sex Among MSM During the Second Wave of COVID-19 in Melbourne, Australia. J Acquir Immune Defic Syndr. 2021;86(2):153–6. [CrossRef ]
41. Mumm J-N, Vilsmaier T, Schuetz JM, Rodler S, Zati Zehni A, Bauer RM, et al. How the COVID-19 Pandemic Affects Sexual Behavior of Hetero-, Homo-, and Bisexual Males in Germany. Sex Med. 2021;9(4):100380. [CrossRef ]
42. Yuksel B, Ozgor F. Effect of the COVID-19 pandemic on female sexual behavior. Int J Gynaecol Obstet. 2020;150(1):98–102. [CrossRef ]
43. Xu J, Zhao S, Teng T, Abdalla AE, Zhu W, Xie L, et al. Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV. Viruses. 2020;12(2):244. [CrossRef ]
44. Tiwari S, Kc N, Thapa S, Ghimire A, Bijukchhe S, Sah GS, Isnuwardana R. Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis. Middle East Fertil Soc J. 2021;26(1):44. [CrossRef ]
45. Erbay G, Sanli A, Turel H, Yavuz U, Erdogan A, Karabakan M, et al. Short-term effects of COVID-19 on semen parameters: A multicenter study of 69 cases. Andrology. 2021;9(4):1060–5. [CrossRef ]
46. Holtmann N, Edimiris P, Andree M, Doehmen C, Baston-Buest D, Adams O, et al. Assessment of SARS-CoV-2 in human semen-a cohort study. Fertil Steril. 2020;114(2):233–8. [CrossRef ]
47. Guo T-H, Sang M-Y, Bai S, Ma H, Wan Y-Y, Jiang X-H, et al. Semen parameters in men recovered from COVID-19. Asian J Androl. 2021;23(5):479–83. [CrossRef ]
48. Ruan Y, Hu B, Liu Z, Liu K, Jiang H, Li H, et al. No detection of SARS-CoV-2 from urine, expressed prostatic secretions, and semen in 74 recovered COVID-19 male patients: A perspective and urogenital evaluation. Andrology. 2021;9(1):99–106. [CrossRef ]
49. Gonzalez DC, Nassau DE, Khodamoradi K, Ibrahim E, Blachman- Braun R, Ory J, Ramasamy R. Sperm Parameters Before and After COVID-19 mRNA Vaccination. JAMA. 2021;326(3):273–4. [CrossRef ]