Alaaddin ÇUKUROVALI, İbrahim YILMAZ

Tiyazol Tabanlı Schiff Bazı ve Metal Komplekslerinin Sentezi ve Antimikrobiyal Aktivite Çalışmaları

Schiff bazları analitik kimyada olduğu kadar boyar maddelerin üretiminde, bazı ilaçlarınhazırlanmasında, elektronik endüstrisinde, plastik sanayiinde ve sıvı kristal teknolojisi gibi çeşitlidallarda gittikçe artan öneme sahip maddelerdir. Bu çalışmada tiyazol tabanlı Schiff bazı ile nikel, bakırve çinko metal kompleksleri sentezlenmiştir. Sentezlenen bileşiklerin yapıları element analizi IR, 1HNMR, 13C NMR spektroskopik yöntemleriyle aydınlatılmıştır. Bileşiklerin bakteri ve mantarlara karşıantimikrobiyal aktiviteleri araştırılmıştır. Ni(II) ve Zn(II) komplekslerinin Staphylococcus aureus a karşızayıf aktivite gösterdiği bulunmuştur.

Synthesis and Antimicrobial Activity Studies of Thiazole Based Schiff Base and Their Metal Complexes

Schiff bases are increasingly important in analytical chemistry as well as in the production of dyes, preparation of certain drugs, electronics industry, plastics industry and various branches such as liquid crystal technology. In this study, thiazole Schiff base and its Cu(II), Ni(II) ve Zn(II) complexes were synthesised. Structures of the synthesised compounds were clarified with elemental analysis, IR, 1H NMR, 13 C NMR spectral techniques. Antimicrobial activities of the compounds have been tested against yeasts and bacterias. Ni(II) ve Zn(II) complexes were found to be weak active against Staphylococcus Aureus.

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