Katyonik Surfaktan Varlığında Kalem Grafit Elektrot Yüzeyinde Epirubisin’in Sıyırma Voltametrisi ile Miktar Tayini

Bu çalışmada, bir antrasiklin ilaç olan epirubisin’in, kalem grafit elektrot kullanarak elektrokimyasalözelliklerini katyonik surfaktan varlığında Britton-Robinson tampon çözeltisinde (pH 2.0-10.0)araştırılmıştır. Öncelikle kalem grafit elektrotun performansını etkileyen parametreler örneğin, elektrotaktivasyonu, destek elektrolit seçimi, pH etkisi, biriktirme gerilimi ve süresi, surfaktan etkisi ve karedalgavoltametrik yöntem parametreleri adsorptif sıyırma voltametrisi tekniği kullanılarak detaylı birşekilde incelenmiştir. Daha sonra önerilen tekniklerin elde edilen en iyi koşullarında epirubisin içindoğrusal aralık (0.01-2.0 μg mL-1) ve gözlenebilme sınırı (GS; 0.0018 μg mL-1) belirlenmiştir. Geliştirilenkare dalga adsorptif sıyırma voltametri tekniği, insan idrarına standart katma tekniğiyle uygulanmıştır.

Voltammetric Determination of Epirubicin using a Pencil Graphite Electrode in the Presence of Cationic Surfactant

In this study, the electrochemical properties of epirubicin, an anthracycline drug using pencil graphite electrode, were investigated in Britton-Robinson buffer (pH 2.0-10.0) in the presence of cationic surfactant. Firstly, parameters affecting the performance of the pencil graphite electrode, such as electrode activation, support electrolyte selection, pH effect, deposition voltage and duration, surfactant effect, and square-wave voltammetric method parameters were investigated in detail by using adsorptive stripping voltammetry technique. Then, the linearity of epirubicin (0.01-2.0 μg mL-1) was determined as the detection limit (LOD; 0.0018 μg mL-1) in the best conditions obtained in the proposed techniques. The developed square wave adsorptive stripping voltammetry technique was applied to the human urine with standard addition technique.

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