Sena Destan BÜNÜL, Beyza CANİK, Hüsnü EFENDİ

Nöromyelitis Optika ve Multipl Sklerozlu Bireylerde İlk Demiyelinizan Atakta İnflamatuar Belirteçlerin Karşılaştırılması

Amaç: Bu çalışmanın amacı, nöromyelitis spektrum hastalıkları (NMOSD) ve multipl skleroz (MS) hastalarında ilk akut atak döneminde periferik kan enflamasyon belirteçlerini değerlendirmek ve bu belirteçlerin hastalıklar arasındaki farklılıkları ortaya koymaktır. Yöntem: Çalışmaya Kocaeli Üniversitesi Tıp Fakültesi Nöroloji anabilim dalı MS polikliniği tarafından izlenen hastalara ait veriler retrospektif olarak dahil edildi. NMOSD ve MS tanıları 2015 ve 2017 kriterlerine göre konuldu. İlk akut atak döneminde, NLR, PLR, MLR, SII, AISI ve SIRI gibi enflamatuvar parametreler, periferik kan örneklerinden hesaplandı. Hastaların demografik özellikleri ve EDSS skorları kayıt programından alındı. Bulgular: Toplam 44 hasta çalışmaya dahil edildi. NMO tanılı hastaların NLR, PLR, SII ve SIRI değerleri, MS hastalarına göre anlamlı derecede yüksekti. Bu sonuçlar, NMOSD ve MS'nin immunpatogenezindeki farklılıkları yansıtabilir. Sonuç: NLR, PLR, SII ve SIRI gibi enflamatuvar belirteçlerin NMOSD ve MS ayırıcı tanısında kullanılabileceği ve hastalığın başlangıç dönemindeki enflamatuvar aktiviteyi değerlendirmede önemli bir rol oynayabileceği düşünülmektedir. Bu bulgular, daha büyük ve çok merkezli çalışmalarla doğrulanmalıdır.

Anahtar Kelimeler:

multipl skleroz, nöromiyelitis optika, inflamasyon, nörodejenerasyon, demiyelinizasyon

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